Study on the anti-hair loss effect of Black Ginseng
[Objective] To establish an androgenic alopecia model in C57BL/6 mice, observe the improvement effect of Black Ginseng extract on alopecia, and explore its mechanism using network pharmacology and molecular docking methods. [Methods] An androgenic alopecia model was established by subcutaneous injec...
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| Format: | Article |
| Language: | zho |
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Editorial Office of International Journal of Geriatrics
2025-03-01
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| Series: | Guoji laonian yixue zazhi |
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| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.02.009&lang=en |
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| _version_ | 1849394742299721728 |
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| author | Yang Ting Zhou Mingjuan Liu Hanlin Xu Mengdi Qi Zhanwen Qi Te Liu Jinping Wang Cuizhu Geng Xiaoyu |
| author_facet | Yang Ting Zhou Mingjuan Liu Hanlin Xu Mengdi Qi Zhanwen Qi Te Liu Jinping Wang Cuizhu Geng Xiaoyu |
| author_sort | Yang Ting |
| collection | DOAJ |
| description | [Objective] To establish an androgenic alopecia model in C57BL/6 mice, observe the improvement effect of Black Ginseng extract on alopecia, and explore its mechanism using network pharmacology and molecular docking methods. [Methods] An androgenic alopecia model was established by subcutaneous injection of testosterone propionate in mice. Different doses of Black Ginseng extract groups were set up and compared with Minoxidil. The improvement effect of Black Ginseng extract on androgenic alopecia was evaluated based on hair growth, dermal thickness, hair follicle morphology and count, serum hormone levels, and skin tissue VEGF and TGF-β content. Based on previous studies, the chemical constituents of Black Ginseng extract were identified. Swiss Target Prediction and Symmap databases were used to obtain targets of Black Ginseng’s chemical constituents, combined with alopecia-related targets from Malacard, DisGeNET, and Genecards databases to construct a "Black Ginseng-chemical composition-intersection target-alopecia" interaction network, screening key chemical components and targets, followed by molecular docking analysis. [Results] Mice in the Black Ginseng extract groups showed better hair growth than the model group, with increased dermal thickness, decreased serum testosterone and dihydrotestosterone levels, increased estradiol levels, increased VEGF expression, and decreased TGF-β expression in skin, all in a dose-dependent manner. Key chemical components Deoxyoleanolic acid, Ginsenoside Rb1, Ginsenoside Rg3, Ginsenoside Rh4, and Campesterol, as well as key targets INS, AR, VEGFA, PPARG, LEP, and CASP3, were identified. Molecular docking results showed stable binding between key components and targets. [Conclusion] Black Ginseng extract improves androgen-induced alopecia in mice, likely by regulating targets such as AR and pathways like MAPK. This provides a scientific basis for further research and development of Black Ginseng. |
| format | Article |
| id | doaj-art-214e9fbacb2d4491bd16ff5b81115748 |
| institution | Kabale University |
| issn | 1674-7593 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of International Journal of Geriatrics |
| record_format | Article |
| series | Guoji laonian yixue zazhi |
| spelling | doaj-art-214e9fbacb2d4491bd16ff5b811157482025-08-20T03:39:54ZzhoEditorial Office of International Journal of GeriatricsGuoji laonian yixue zazhi1674-75932025-03-0146217418410.3969/j.issn.1674-7593.2025.02.009Study on the anti-hair loss effect of Black GinsengYang Ting0Zhou Mingjuan1Liu Hanlin2Xu Mengdi3Qi Zhanwen4Qi Te5Liu Jinping6Wang Cuizhu7Geng Xiaoyu8College of Pharmacy, Jilin University, Changchun 130021College of Chemistry, Jilin University, Changchun 130000College of Pharmacy, Jilin University, Changchun 130021College of Pharmacy, Jilin University, Changchun 130021Yanbian Hangongfang Health Products Co. Ltd., Yanji 133000Yanbian Hangongfang Health Products Co. Ltd., Yanji 133000College of Pharmacy, Jilin University, Changchun 130021College of Pharmacy, Jilin University, Changchun 130021College of Pharmacy, Tonghua Normal University, Tonghua 134002[Objective] To establish an androgenic alopecia model in C57BL/6 mice, observe the improvement effect of Black Ginseng extract on alopecia, and explore its mechanism using network pharmacology and molecular docking methods. [Methods] An androgenic alopecia model was established by subcutaneous injection of testosterone propionate in mice. Different doses of Black Ginseng extract groups were set up and compared with Minoxidil. The improvement effect of Black Ginseng extract on androgenic alopecia was evaluated based on hair growth, dermal thickness, hair follicle morphology and count, serum hormone levels, and skin tissue VEGF and TGF-β content. Based on previous studies, the chemical constituents of Black Ginseng extract were identified. Swiss Target Prediction and Symmap databases were used to obtain targets of Black Ginseng’s chemical constituents, combined with alopecia-related targets from Malacard, DisGeNET, and Genecards databases to construct a "Black Ginseng-chemical composition-intersection target-alopecia" interaction network, screening key chemical components and targets, followed by molecular docking analysis. [Results] Mice in the Black Ginseng extract groups showed better hair growth than the model group, with increased dermal thickness, decreased serum testosterone and dihydrotestosterone levels, increased estradiol levels, increased VEGF expression, and decreased TGF-β expression in skin, all in a dose-dependent manner. Key chemical components Deoxyoleanolic acid, Ginsenoside Rb1, Ginsenoside Rg3, Ginsenoside Rh4, and Campesterol, as well as key targets INS, AR, VEGFA, PPARG, LEP, and CASP3, were identified. Molecular docking results showed stable binding between key components and targets. [Conclusion] Black Ginseng extract improves androgen-induced alopecia in mice, likely by regulating targets such as AR and pathways like MAPK. This provides a scientific basis for further research and development of Black Ginseng.http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.02.009&lang=enblack ginsenghair lossandrogenetic alopecianetwork pharmacologymolecular docking |
| spellingShingle | Yang Ting Zhou Mingjuan Liu Hanlin Xu Mengdi Qi Zhanwen Qi Te Liu Jinping Wang Cuizhu Geng Xiaoyu Study on the anti-hair loss effect of Black Ginseng Guoji laonian yixue zazhi black ginseng hair loss androgenetic alopecia network pharmacology molecular docking |
| title | Study on the anti-hair loss effect of Black Ginseng |
| title_full | Study on the anti-hair loss effect of Black Ginseng |
| title_fullStr | Study on the anti-hair loss effect of Black Ginseng |
| title_full_unstemmed | Study on the anti-hair loss effect of Black Ginseng |
| title_short | Study on the anti-hair loss effect of Black Ginseng |
| title_sort | study on the anti hair loss effect of black ginseng |
| topic | black ginseng hair loss androgenetic alopecia network pharmacology molecular docking |
| url | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.02.009&lang=en |
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