Cell-targeted PD-1 agonists are potent NK-cell inhibitors

Cell-targeted PD-1 agonists are potent NK-cell inhibitors

BackgroundThe programmed cell death protein 1 (PDCD1 or PD-1) is a key regulatory immune checkpoint and a major target for therapeutic intervention. In oncology, antibodies blocking the PD-1 pathway are used to activate immune cells to promote anti tumour immunity while in immune-mediated inflammato...

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Bibliographic Details
Main Authors: Harriet C. Pope, Ana L. Chiodetti, Alice Newey, Guillaume Rieunier, David X. Overton, Eduardo Mateos-Diaz, Tara M. Mahon, Giovanna Bossi, Hussein Al-Mossawi, Charlotte Viant
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
cell-targeted PD-1 agonists
NK cell
type 1 diabetes
autoimmune diseases
NK cell inhibition
PD-1 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1640509/full
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