Association between serum vitamin D and severe headache or migraine: A population-based analysis.
<h4>Background</h4>Vitamin D is thought to play a role in the development of migraine, but the nature of the relationship is still not fully understood. Although some studies have shown an association between vitamin D deficiency and migraine, other studies have had inconsistent or incon...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0313082 |
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| author | Shunfa Hao Renyi Qian Yiru Chen Jingfang Liu Xiaoyan Xu Yunxiang Guan |
| author_facet | Shunfa Hao Renyi Qian Yiru Chen Jingfang Liu Xiaoyan Xu Yunxiang Guan |
| author_sort | Shunfa Hao |
| collection | DOAJ |
| description | <h4>Background</h4>Vitamin D is thought to play a role in the development of migraine, but the nature of the relationship is still not fully understood. Although some studies have shown an association between vitamin D deficiency and migraine, other studies have had inconsistent or inconclusive results. Therefore, further research is needed to better understand the relationship between vitamin D and migraine headaches.<h4>Methods</h4>We selected 9142 participants from the 2001-2004 National Health and Nutrition Examination Survey (NHANES). In our study, the term "serum vitamin D" refers to the concentration of 25OHD2 + 25OHD3 (nmol/L) in the blood. Migraine was assessed based on self-reports in the miscellaneous pain section of the NHANES questionnaire. Associations between vitamin D and the risk of migraine were examined using multiple logistic regression, smoothed curve fitting, and stratified analyses.<h4>Results</h4>In our study, 20.53% of the participants suffered from migraine. The prevalence of migraine was higher in those with lower serum vitamin D levels. Participants in the highest quartile of serum vitamin D levels were found to have a 16% lower prevalence than those in the lowest quartile in the fully adjusted model (OR = 0.84, 95% CI 0.71-0.99). This result was supported by stratified analysis and smoothed curve fitting.<h4>Conclusion</h4>Our study showed a significant negative correlation between serum vitamin D levels and the prevalence of migraine in American adults. |
| format | Article |
| id | doaj-art-214bd03026c04c389cfc461a7504ff6a |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-214bd03026c04c389cfc461a7504ff6a2025-01-08T05:31:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031308210.1371/journal.pone.0313082Association between serum vitamin D and severe headache or migraine: A population-based analysis.Shunfa HaoRenyi QianYiru ChenJingfang LiuXiaoyan XuYunxiang Guan<h4>Background</h4>Vitamin D is thought to play a role in the development of migraine, but the nature of the relationship is still not fully understood. Although some studies have shown an association between vitamin D deficiency and migraine, other studies have had inconsistent or inconclusive results. Therefore, further research is needed to better understand the relationship between vitamin D and migraine headaches.<h4>Methods</h4>We selected 9142 participants from the 2001-2004 National Health and Nutrition Examination Survey (NHANES). In our study, the term "serum vitamin D" refers to the concentration of 25OHD2 + 25OHD3 (nmol/L) in the blood. Migraine was assessed based on self-reports in the miscellaneous pain section of the NHANES questionnaire. Associations between vitamin D and the risk of migraine were examined using multiple logistic regression, smoothed curve fitting, and stratified analyses.<h4>Results</h4>In our study, 20.53% of the participants suffered from migraine. The prevalence of migraine was higher in those with lower serum vitamin D levels. Participants in the highest quartile of serum vitamin D levels were found to have a 16% lower prevalence than those in the lowest quartile in the fully adjusted model (OR = 0.84, 95% CI 0.71-0.99). This result was supported by stratified analysis and smoothed curve fitting.<h4>Conclusion</h4>Our study showed a significant negative correlation between serum vitamin D levels and the prevalence of migraine in American adults.https://doi.org/10.1371/journal.pone.0313082 |
| spellingShingle | Shunfa Hao Renyi Qian Yiru Chen Jingfang Liu Xiaoyan Xu Yunxiang Guan Association between serum vitamin D and severe headache or migraine: A population-based analysis. PLoS ONE |
| title | Association between serum vitamin D and severe headache or migraine: A population-based analysis. |
| title_full | Association between serum vitamin D and severe headache or migraine: A population-based analysis. |
| title_fullStr | Association between serum vitamin D and severe headache or migraine: A population-based analysis. |
| title_full_unstemmed | Association between serum vitamin D and severe headache or migraine: A population-based analysis. |
| title_short | Association between serum vitamin D and severe headache or migraine: A population-based analysis. |
| title_sort | association between serum vitamin d and severe headache or migraine a population based analysis |
| url | https://doi.org/10.1371/journal.pone.0313082 |
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