Endotoxicosis as the Contents of Posresuscitative Disease in Acute Poisoning
Objective: to study the specific features of the diagnosis and treatment of endothoxicosis as a manifestation of postresus-citative disease in acute exogenous poisoning.Subjects and methods. Clinical, laboratory, and statistical methods of the diagnosis of endotoxicosis complicating the course of ac...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2007-12-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/882 |
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| author | Ye. A. Luzhnikov Yu. S. Goldfarb K. K. Ilyashenko |
| author_facet | Ye. A. Luzhnikov Yu. S. Goldfarb K. K. Ilyashenko |
| author_sort | Ye. A. Luzhnikov |
| collection | DOAJ |
| description | Objective: to study the specific features of the diagnosis and treatment of endothoxicosis as a manifestation of postresus-citative disease in acute exogenous poisoning.Subjects and methods. Clinical, laboratory, and statistical methods of the diagnosis of endotoxicosis complicating the course of acute poisoning by narcotics, psychopharmacological agents, and cauterants, as well as complex physicochemical detoxification were applied to 554 patients.Results. The study pathology has been ascertained to have 3 developmental stages — from functional (primary) to developed and terminal clinical and laboratory manifestations as multiple organ dysfunctions. The best therapeutic results are achieved by effective therapeutic measures just in early-stage endotoxicosis, by substantially reducing the rates of death and pneumonia and the time of the latter’s resolution. The major contribution to the reduction in the rate of death due acute poisoning is associated with physicochemical detoxification that considerably lessens the influence of the intoxication factors of postresuscitative disease.Conclusion. When diagnosing endotoxicosis in patients with acute endogenous intoxication, it is necessary to keep in mind a whole spectrum of typical changes in endotoxicosis markers and homeostatic parameters: hematologi-cal, blood rheological, lipid peroxidation/antioxidative systems, which should be timely corrected by the basic efferent artificial detoxification techniques (hemosorption, hemodiafiltration, hemofiltration), by compulsorily employing physio-and chemohemotherapy (laser-ultraviolet hemotherapy, sodium hypochlorite infusion). |
| format | Article |
| id | doaj-art-214b4e43292a4760aaae9e5be5865b97 |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2007-12-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-214b4e43292a4760aaae9e5be5865b972025-08-20T03:43:41ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102007-12-0136485410.15360/1813-9779-2007-6-48-54882Endotoxicosis as the Contents of Posresuscitative Disease in Acute PoisoningYe. A. Luzhnikov0Yu. S. Goldfarb1K. K. Ilyashenko2N. V. Sklifosovsky Research Institute of Emergency Care, MoscowN. V. Sklifosovsky Research Institute of Emergency Care, MoscowN. V. Sklifosovsky Research Institute of Emergency Care, MoscowObjective: to study the specific features of the diagnosis and treatment of endothoxicosis as a manifestation of postresus-citative disease in acute exogenous poisoning.Subjects and methods. Clinical, laboratory, and statistical methods of the diagnosis of endotoxicosis complicating the course of acute poisoning by narcotics, psychopharmacological agents, and cauterants, as well as complex physicochemical detoxification were applied to 554 patients.Results. The study pathology has been ascertained to have 3 developmental stages — from functional (primary) to developed and terminal clinical and laboratory manifestations as multiple organ dysfunctions. The best therapeutic results are achieved by effective therapeutic measures just in early-stage endotoxicosis, by substantially reducing the rates of death and pneumonia and the time of the latter’s resolution. The major contribution to the reduction in the rate of death due acute poisoning is associated with physicochemical detoxification that considerably lessens the influence of the intoxication factors of postresuscitative disease.Conclusion. When diagnosing endotoxicosis in patients with acute endogenous intoxication, it is necessary to keep in mind a whole spectrum of typical changes in endotoxicosis markers and homeostatic parameters: hematologi-cal, blood rheological, lipid peroxidation/antioxidative systems, which should be timely corrected by the basic efferent artificial detoxification techniques (hemosorption, hemodiafiltration, hemofiltration), by compulsorily employing physio-and chemohemotherapy (laser-ultraviolet hemotherapy, sodium hypochlorite infusion).https://www.reanimatology.com/rmt/article/view/882acute intoxicationsendotoxicosisphysiochemical detoxification |
| spellingShingle | Ye. A. Luzhnikov Yu. S. Goldfarb K. K. Ilyashenko Endotoxicosis as the Contents of Posresuscitative Disease in Acute Poisoning Общая реаниматология acute intoxications endotoxicosis physiochemical detoxification |
| title | Endotoxicosis as the Contents of Posresuscitative Disease in Acute Poisoning |
| title_full | Endotoxicosis as the Contents of Posresuscitative Disease in Acute Poisoning |
| title_fullStr | Endotoxicosis as the Contents of Posresuscitative Disease in Acute Poisoning |
| title_full_unstemmed | Endotoxicosis as the Contents of Posresuscitative Disease in Acute Poisoning |
| title_short | Endotoxicosis as the Contents of Posresuscitative Disease in Acute Poisoning |
| title_sort | endotoxicosis as the contents of posresuscitative disease in acute poisoning |
| topic | acute intoxications endotoxicosis physiochemical detoxification |
| url | https://www.reanimatology.com/rmt/article/view/882 |
| work_keys_str_mv | AT yealuzhnikov endotoxicosisasthecontentsofposresuscitativediseaseinacutepoisoning AT yusgoldfarb endotoxicosisasthecontentsofposresuscitativediseaseinacutepoisoning AT kkilyashenko endotoxicosisasthecontentsofposresuscitativediseaseinacutepoisoning |