A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same Patient
Richter transformation (RT) is a rare sequelae of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The clonal relationship of the RT to the underlined CLL/SLL is an important prognostic factor as clonally related RT has a worse prognosis than that of clonally unrelated RT. The de...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2024/7913296 |
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| author | Michelle D. Don Carlos Casiano Huan-You Wang Mikhail Gorbounov Wei Song Edward D. Ball |
| author_facet | Michelle D. Don Carlos Casiano Huan-You Wang Mikhail Gorbounov Wei Song Edward D. Ball |
| author_sort | Michelle D. Don |
| collection | DOAJ |
| description | Richter transformation (RT) is a rare sequelae of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The clonal relationship of the RT to the underlined CLL/SLL is an important prognostic factor as clonally related RT has a worse prognosis than that of clonally unrelated RT. The development of more than one RT in the same patient is exceedingly rare and prior reports have shown cases consisting of RT to diffuse large B-cell lymphoma (DLBCL) and a subsequent or synchronous Hodgkin lymphoma. Here, we present a rare case of RT first to a clonally unrelated DLBCL and subsequently a clonally related DLBCL. Additionally, we retrospectively conducted next-generation sequencing studies of both RT’s and found different mutational landscapes, including more clinically aggressive mutations identified in the clonally related RT. To our knowledge, this is the first reported case of clonally related and clonally unrelated RT, both of which are DLBCL, in the same patient. |
| format | Article |
| id | doaj-art-2147dc1820ed4552b9e24eab7dc12eaf |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-2147dc1820ed4552b9e24eab7dc12eaf2025-02-03T10:18:13ZengWileyCase Reports in Hematology2090-65792024-01-01202410.1155/2024/7913296A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same PatientMichelle D. Don0Carlos Casiano1Huan-You Wang2Mikhail Gorbounov3Wei Song4Edward D. Ball5Division of Laboratory and Genomic MedicineDivision of Laboratory and Genomic MedicineDivision of Laboratory and Genomic MedicineDivision of Laboratory and Genomic MedicineDivision of Laboratory and Genomic MedicineDivision of Blood and Marrow TransplantRichter transformation (RT) is a rare sequelae of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The clonal relationship of the RT to the underlined CLL/SLL is an important prognostic factor as clonally related RT has a worse prognosis than that of clonally unrelated RT. The development of more than one RT in the same patient is exceedingly rare and prior reports have shown cases consisting of RT to diffuse large B-cell lymphoma (DLBCL) and a subsequent or synchronous Hodgkin lymphoma. Here, we present a rare case of RT first to a clonally unrelated DLBCL and subsequently a clonally related DLBCL. Additionally, we retrospectively conducted next-generation sequencing studies of both RT’s and found different mutational landscapes, including more clinically aggressive mutations identified in the clonally related RT. To our knowledge, this is the first reported case of clonally related and clonally unrelated RT, both of which are DLBCL, in the same patient.http://dx.doi.org/10.1155/2024/7913296 |
| spellingShingle | Michelle D. Don Carlos Casiano Huan-You Wang Mikhail Gorbounov Wei Song Edward D. Ball A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same Patient Case Reports in Hematology |
| title | A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same Patient |
| title_full | A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same Patient |
| title_fullStr | A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same Patient |
| title_full_unstemmed | A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same Patient |
| title_short | A Rare Case of Richter Transformation to Both Clonally Unrelated and Clonally Related Diffuse Large B-Cell Lymphoma in the Same Patient |
| title_sort | rare case of richter transformation to both clonally unrelated and clonally related diffuse large b cell lymphoma in the same patient |
| url | http://dx.doi.org/10.1155/2024/7913296 |
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