The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical Applications
Upconversion and near-infrared emitting Gd2O3:Er3+,Yb3+ nanostructured phosphors (nanoparticles and nanorods) for applications in bioimaging have been synthesized by precipitation methods and hydrothermal treatment. Variation of the material synthesis conditions (additives and pH) allows controlling...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2012/748098 |
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| author | Eva Hemmer Nallusamy Venkatachalam Hiroshi Hyodo Kohei Soga |
| author_facet | Eva Hemmer Nallusamy Venkatachalam Hiroshi Hyodo Kohei Soga |
| author_sort | Eva Hemmer |
| collection | DOAJ |
| description | Upconversion and near-infrared emitting Gd2O3:Er3+,Yb3+ nanostructured phosphors (nanoparticles and nanorods) for applications in bioimaging have been synthesized by precipitation methods and hydrothermal treatment. Variation of the material synthesis conditions (additives and pH) allows controlling particle size (40 nm to μm range) and rod aspect ratio (5 to 18). It was shown that PEG-b-PAAc (poly(ethylene glycol) poly(acrylic acid) block polymer) is suitable to provide the required chemical durability, dispersion stability, and noncytotoxic behaviour for biomedical applications, where the coating of Gd2O3 with a protecting and biocompatible layer is essential in order to prevent the release of toxic Gd3+ ions. Physicochemical properties of the Gd2O3:Er3+,Yb3+ nanostructures modified with PEG-b-PAAc have been investigated by TG-DTA, FT-IR, and DLS revealing a strong influence of modification conditions, namely, pH of the reaction media, on the nature of the PEG-b-PAAc layer. |
| format | Article |
| id | doaj-art-21460502f6b344b38294f7a4ca08b114 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-21460502f6b344b38294f7a4ca08b1142025-02-03T05:54:29ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422012-01-01201210.1155/2012/748098748098The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical ApplicationsEva Hemmer0Nallusamy Venkatachalam1Hiroshi Hyodo2Kohei Soga3Center for Technologies against Cancer (CTC), Tokyo University of Science, 2669 Yamazaki Noda, Chiba 278-0022, JapanDepartment of Materials Science and Technology, Tokyo University of Science, 2641 Yamazaki Noda, Chiba 278-8510, JapanDepartment of Materials Science and Technology, Tokyo University of Science, 2641 Yamazaki Noda, Chiba 278-8510, JapanCenter for Technologies against Cancer (CTC), Tokyo University of Science, 2669 Yamazaki Noda, Chiba 278-0022, JapanUpconversion and near-infrared emitting Gd2O3:Er3+,Yb3+ nanostructured phosphors (nanoparticles and nanorods) for applications in bioimaging have been synthesized by precipitation methods and hydrothermal treatment. Variation of the material synthesis conditions (additives and pH) allows controlling particle size (40 nm to μm range) and rod aspect ratio (5 to 18). It was shown that PEG-b-PAAc (poly(ethylene glycol) poly(acrylic acid) block polymer) is suitable to provide the required chemical durability, dispersion stability, and noncytotoxic behaviour for biomedical applications, where the coating of Gd2O3 with a protecting and biocompatible layer is essential in order to prevent the release of toxic Gd3+ ions. Physicochemical properties of the Gd2O3:Er3+,Yb3+ nanostructures modified with PEG-b-PAAc have been investigated by TG-DTA, FT-IR, and DLS revealing a strong influence of modification conditions, namely, pH of the reaction media, on the nature of the PEG-b-PAAc layer.http://dx.doi.org/10.1155/2012/748098 |
| spellingShingle | Eva Hemmer Nallusamy Venkatachalam Hiroshi Hyodo Kohei Soga The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical Applications Advances in Materials Science and Engineering |
| title | The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical Applications |
| title_full | The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical Applications |
| title_fullStr | The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical Applications |
| title_full_unstemmed | The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical Applications |
| title_short | The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical Applications |
| title_sort | role of ph in peg b paac modification of gadolinium oxide nanostructures for biomedical applications |
| url | http://dx.doi.org/10.1155/2012/748098 |
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