Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injury
Abstract Hepatic ischemia-reperfusion injury (HIRI) severely threatens the success rates of liver surgery and transplantation. Its complex pathological process involves multiple factors such as oxidative stress, inflammatory responses, and ferroptosis, creating an urgent need for new therapeutic str...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-025-04302-9 |
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| author | Bo Zhao Jiping Wei Zijian Jiang Yiming Long Yan Xu Botao Jiang |
| author_facet | Bo Zhao Jiping Wei Zijian Jiang Yiming Long Yan Xu Botao Jiang |
| author_sort | Bo Zhao |
| collection | DOAJ |
| description | Abstract Hepatic ischemia-reperfusion injury (HIRI) severely threatens the success rates of liver surgery and transplantation. Its complex pathological process involves multiple factors such as oxidative stress, inflammatory responses, and ferroptosis, creating an urgent need for new therapeutic strategies. Exosomes derived from mesenchymal stem cells (MSCs) are emerging as a next-generation acellular therapeutic approach. With their outstanding immune-regulatory capabilities, significant reparative functions, and good biocompatibility, they are leading innovations in the field of HIRI treatment. This article provides a systematic comparison of the therapeutic characteristics of MSC-derived exosomes(MSC-EXOs) from four different sources: adipose tissue, bone marrow, umbilical cord, and induced pluripotent stem cells. Although the clinical translation of MSC-EXOs still faces challenges such as variations in isolation methods, large-scale production, and safety assessments, their remarkable therapeutic effects and vast application potential signal the arrival of a new era of precision treatment for HIRI. This review not only provides a comprehensive theoretical foundation to promote the clinical application of MSC-EXOs but also opens up innovative research directions in the field of regenerative medicine. |
| format | Article |
| id | doaj-art-213fb3ce000b49dc8f6cf18b0223e1f0 |
| institution | OA Journals |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-213fb3ce000b49dc8f6cf18b0223e1f02025-08-20T02:17:46ZengBMCStem Cell Research & Therapy1757-65122025-04-0116111310.1186/s13287-025-04302-9Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injuryBo Zhao0Jiping Wei1Zijian Jiang2Yiming Long3Yan Xu4Botao Jiang5School of Pharmacy, Xianning Medical College, Hubei University of Science and TechnologySchool of Pharmacy, Xianning Medical College, Hubei University of Science and TechnologyYangtze UniversitySchool of Pharmacy, Xianning Medical College, Hubei University of Science and TechnologySchool of Pharmacy, Xianning Medical College, Hubei University of Science and TechnologyDepartment of Urology, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and TechnologyAbstract Hepatic ischemia-reperfusion injury (HIRI) severely threatens the success rates of liver surgery and transplantation. Its complex pathological process involves multiple factors such as oxidative stress, inflammatory responses, and ferroptosis, creating an urgent need for new therapeutic strategies. Exosomes derived from mesenchymal stem cells (MSCs) are emerging as a next-generation acellular therapeutic approach. With their outstanding immune-regulatory capabilities, significant reparative functions, and good biocompatibility, they are leading innovations in the field of HIRI treatment. This article provides a systematic comparison of the therapeutic characteristics of MSC-derived exosomes(MSC-EXOs) from four different sources: adipose tissue, bone marrow, umbilical cord, and induced pluripotent stem cells. Although the clinical translation of MSC-EXOs still faces challenges such as variations in isolation methods, large-scale production, and safety assessments, their remarkable therapeutic effects and vast application potential signal the arrival of a new era of precision treatment for HIRI. This review not only provides a comprehensive theoretical foundation to promote the clinical application of MSC-EXOs but also opens up innovative research directions in the field of regenerative medicine.https://doi.org/10.1186/s13287-025-04302-9Hepatic Ischemia-Reperfusion Injury(HIRI)MSC-derived exosomes(MSC-EXOs)FerroptosisTherapeutic standardizationRegenerative medicine |
| spellingShingle | Bo Zhao Jiping Wei Zijian Jiang Yiming Long Yan Xu Botao Jiang Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injury Stem Cell Research & Therapy Hepatic Ischemia-Reperfusion Injury(HIRI) MSC-derived exosomes(MSC-EXOs) Ferroptosis Therapeutic standardization Regenerative medicine |
| title | Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injury |
| title_full | Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injury |
| title_fullStr | Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injury |
| title_full_unstemmed | Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injury |
| title_short | Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injury |
| title_sort | mesenchymal stem cell derived exosomes an emerging therapeutic strategy for hepatic ischemia reperfusion injury |
| topic | Hepatic Ischemia-Reperfusion Injury(HIRI) MSC-derived exosomes(MSC-EXOs) Ferroptosis Therapeutic standardization Regenerative medicine |
| url | https://doi.org/10.1186/s13287-025-04302-9 |
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