Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial
Atopic dermatitis is a chronic inflammatory skin disease characterized by flare-ups of inflamed, dry, and itchy skin affecting over 200 million people worldwide. “Emollients plus” containing active cosmetic ingredients such as herbal extracts and phytochemicals have the potential to surpass the effi...
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| Format: | Article |
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Medical Journals Sweden
2025-06-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/43026 |
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| author | Lars Herrmann Stanislav Andreev Ramona Ziegler Christine Neubauer Kathrin Moritz Nicole Maehler Hubert Steindl Stephan Daehnhardt-Pfeiffer Christoph Abels |
| author_facet | Lars Herrmann Stanislav Andreev Ramona Ziegler Christine Neubauer Kathrin Moritz Nicole Maehler Hubert Steindl Stephan Daehnhardt-Pfeiffer Christoph Abels |
| author_sort | Lars Herrmann |
| collection | DOAJ |
| description | Atopic dermatitis is a chronic inflammatory skin disease characterized by flare-ups of inflamed, dry, and itchy skin affecting over 200 million people worldwide. “Emollients plus” containing active cosmetic ingredients such as herbal extracts and phytochemicals have the potential to surpass the efficacy of conventional emollients, while avoiding side effects associated with pharmacological interventions. The reported 12-week clinical trial (NCT05790083) evaluated long-term efficacy and tolerability of oil-in-water emulsions BNO 3731 and BNO 3732 containing ginger extract and cannabidiol as basic emollient therapy for atopic dermatitis. A total of 100 adults and children with a history of atopic dermatitis were included and applied BNO 3732 (body lotion) twice daily and BNO 3731 (intensive care product) as needed. Over 12 weeks the emollients plus combination led to sustained improvement of peak pruritus and patient-reported outcome measures, i.e., “Recap of atopic eczema”. Objective dermatological evaluation showed progressive improvements for vIGA-ADTM and isolated symptoms, i.e., erythema and dryness. Instrumental analysis of intercellular lipid contents and lipid lamellae organization in the stratum corneum demonstrated recovery of the epidermal barrier integrity. The clinical results provide evidence on the efficacy of herbal emollients plus beyond mere moisturizing and occlusive properties. BNO 3731 and BNO 3732 were very well tolerated.
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| format | Article |
| id | doaj-art-2137e17372824aff83dbb67dbcc854b3 |
| institution | Kabale University |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-2137e17372824aff83dbb67dbcc854b32025-08-20T03:30:43ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-06-0110510.2340/actadv.v105.43026Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical TrialLars Herrmann0https://orcid.org/0000-0002-9206-2115Stanislav Andreev1https://orcid.org/0000-0001-7098-4445Ramona Ziegler2Christine Neubauer3Kathrin Moritz4Nicole Maehler5Hubert Steindl6Stephan Daehnhardt-Pfeiffer7Christoph Abels8https://orcid.org/0000-0002-7778-7740Bionorica SE, Neumarkt, GermanyBionorica SE, Neumarkt, GermanyBionorica SE, Neumarkt, GermanyBionorica SE, Neumarkt, GermanyBionorica SE, Neumarkt, GermanyBionorica SE, Neumarkt, GermanyBionorica SE, Neumarkt, GermanyMicroscopy Services Dähnhardt GmbH, Flintbek, GermanyBionorica SE, Neumarkt, GermanyAtopic dermatitis is a chronic inflammatory skin disease characterized by flare-ups of inflamed, dry, and itchy skin affecting over 200 million people worldwide. “Emollients plus” containing active cosmetic ingredients such as herbal extracts and phytochemicals have the potential to surpass the efficacy of conventional emollients, while avoiding side effects associated with pharmacological interventions. The reported 12-week clinical trial (NCT05790083) evaluated long-term efficacy and tolerability of oil-in-water emulsions BNO 3731 and BNO 3732 containing ginger extract and cannabidiol as basic emollient therapy for atopic dermatitis. A total of 100 adults and children with a history of atopic dermatitis were included and applied BNO 3732 (body lotion) twice daily and BNO 3731 (intensive care product) as needed. Over 12 weeks the emollients plus combination led to sustained improvement of peak pruritus and patient-reported outcome measures, i.e., “Recap of atopic eczema”. Objective dermatological evaluation showed progressive improvements for vIGA-ADTM and isolated symptoms, i.e., erythema and dryness. Instrumental analysis of intercellular lipid contents and lipid lamellae organization in the stratum corneum demonstrated recovery of the epidermal barrier integrity. The clinical results provide evidence on the efficacy of herbal emollients plus beyond mere moisturizing and occlusive properties. BNO 3731 and BNO 3732 were very well tolerated. https://medicaljournalssweden.se/actadv/article/view/43026Atopic dermatitisBasic emollient therapyClinical trialEmollient plusHerbal ingredientsPhytochemicals |
| spellingShingle | Lars Herrmann Stanislav Andreev Ramona Ziegler Christine Neubauer Kathrin Moritz Nicole Maehler Hubert Steindl Stephan Daehnhardt-Pfeiffer Christoph Abels Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial Acta Dermato-Venereologica Atopic dermatitis Basic emollient therapy Clinical trial Emollient plus Herbal ingredients Phytochemicals |
| title | Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial |
| title_full | Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial |
| title_fullStr | Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial |
| title_full_unstemmed | Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial |
| title_short | Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial |
| title_sort | long term progressive improvement of atopic dermatitis by an herbal emollient plus combination in a 12 week clinical trial |
| topic | Atopic dermatitis Basic emollient therapy Clinical trial Emollient plus Herbal ingredients Phytochemicals |
| url | https://medicaljournalssweden.se/actadv/article/view/43026 |
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