Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exercise
Abstract We investigated how obesity impacts the response of circulating insulin‐like growth factor‐1 (IGF‐1) to a single bout of endurance exercise in humans with and without obesity. Blood samples were collected before exercise, at 15 and 40 min during a 45‐min cycling session at 65% of heart rate...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70436 |
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| author | Eduardo D. S. Freitas Lori R. Roust Eleanna De Filippis Matthew Buras Brooke Brown Christos S. Katsanos |
| author_facet | Eduardo D. S. Freitas Lori R. Roust Eleanna De Filippis Matthew Buras Brooke Brown Christos S. Katsanos |
| author_sort | Eduardo D. S. Freitas |
| collection | DOAJ |
| description | Abstract We investigated how obesity impacts the response of circulating insulin‐like growth factor‐1 (IGF‐1) to a single bout of endurance exercise in humans with and without obesity. Blood samples were collected before exercise, at 15 and 40 min during a 45‐min cycling session at 65% of heart rate reserve, and 15 min post‐exercise. Serum levels of total IGF‐1, free IGF‐1, IGF binding proteins 1 (IGFBP‐1) and 3 (IGFBP‐3), growth hormone, and insulin were measured. Both total IGF‐1 and IGFBP‐3 serum concentrations increased significantly (p < 0.05) during exercise in the study participants without obesity but not in those with obesity, returning to basal levels immediately after exercise. There was a statistically significant main effect on the growth hormone response, with circulating levels being higher in participants without obesity (p < 0.05). No significant effects were observed for either free IGF‐1 or IGFBP‐1 serum concentrations in response to exercise in either group (p > 0.05). We conclude that humans with obesity have blunted serum total IGF‐1 response during exercise. However, a concurrent attenuation in serum IGFBP‐3 response, which regulates free (i.e., biologically active) IGF‐1 in circulation, results in no change in circulating free IGF‐1 levels during endurance exercise in individuals with obesity. |
| format | Article |
| id | doaj-art-2133c38c1b044caea6e427468e7d6304 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-2133c38c1b044caea6e427468e7d63042025-08-20T03:31:56ZengWileyPhysiological Reports2051-817X2025-06-011312n/an/a10.14814/phy2.70436Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exerciseEduardo D. S. Freitas0Lori R. Roust1Eleanna De Filippis2Matthew Buras3Brooke Brown4Christos S. Katsanos5School of Life Sciences Arizona State University Tempe Arizona USACollege of Medicine Mayo Clinic Arizona Scottsdale Arizona USACollege of Medicine Mayo Clinic Arizona Scottsdale Arizona USADepartment of Biomedical Informatics Mayo Clinic Arizona Scottsdale Arizona USAClinical Studies Unit Mayo Clinic Arizona Scottsdale Arizona USASchool of Life Sciences Arizona State University Tempe Arizona USAAbstract We investigated how obesity impacts the response of circulating insulin‐like growth factor‐1 (IGF‐1) to a single bout of endurance exercise in humans with and without obesity. Blood samples were collected before exercise, at 15 and 40 min during a 45‐min cycling session at 65% of heart rate reserve, and 15 min post‐exercise. Serum levels of total IGF‐1, free IGF‐1, IGF binding proteins 1 (IGFBP‐1) and 3 (IGFBP‐3), growth hormone, and insulin were measured. Both total IGF‐1 and IGFBP‐3 serum concentrations increased significantly (p < 0.05) during exercise in the study participants without obesity but not in those with obesity, returning to basal levels immediately after exercise. There was a statistically significant main effect on the growth hormone response, with circulating levels being higher in participants without obesity (p < 0.05). No significant effects were observed for either free IGF‐1 or IGFBP‐1 serum concentrations in response to exercise in either group (p > 0.05). We conclude that humans with obesity have blunted serum total IGF‐1 response during exercise. However, a concurrent attenuation in serum IGFBP‐3 response, which regulates free (i.e., biologically active) IGF‐1 in circulation, results in no change in circulating free IGF‐1 levels during endurance exercise in individuals with obesity.https://doi.org/10.14814/phy2.70436exercisegrowth hormoneIGF‐1IGFBP‐1IGFBP‐3obesity |
| spellingShingle | Eduardo D. S. Freitas Lori R. Roust Eleanna De Filippis Matthew Buras Brooke Brown Christos S. Katsanos Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exercise Physiological Reports exercise growth hormone IGF‐1 IGFBP‐1 IGFBP‐3 obesity |
| title | Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exercise |
| title_full | Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exercise |
| title_fullStr | Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exercise |
| title_full_unstemmed | Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exercise |
| title_short | Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exercise |
| title_sort | humans with obesity exhibit impaired circulating total but not free igf 1 response to acute endurance exercise |
| topic | exercise growth hormone IGF‐1 IGFBP‐1 IGFBP‐3 obesity |
| url | https://doi.org/10.14814/phy2.70436 |
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