Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review
Simultaneous occurrence of primary hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is rare. We report two cases of synchronous double primary HCC and ICC (sdpHCC-ICC), both associated with chronic hepatitis B. Case 1 involves a 63-year-old man whose liver lesions were incide...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1507454/full |
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| author | Pengcheng Wei Pengcheng Wei Pengcheng Wei Nan Kang Chen Lo Chen Lo Chen Lo Yongjing Luo Yongjing Luo Yongjing Luo Jie Gao Jie Gao Jie Gao Jie Gao Jiye Zhu Jiye Zhu Jiye Zhu Jiye Zhu Zhao Li Zhao Li Zhao Li Zhao Li |
| author_facet | Pengcheng Wei Pengcheng Wei Pengcheng Wei Nan Kang Chen Lo Chen Lo Chen Lo Yongjing Luo Yongjing Luo Yongjing Luo Jie Gao Jie Gao Jie Gao Jie Gao Jiye Zhu Jiye Zhu Jiye Zhu Jiye Zhu Zhao Li Zhao Li Zhao Li Zhao Li |
| author_sort | Pengcheng Wei |
| collection | DOAJ |
| description | Simultaneous occurrence of primary hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is rare. We report two cases of synchronous double primary HCC and ICC (sdpHCC-ICC), both associated with chronic hepatitis B. Case 1 involves a 63-year-old man whose liver lesions were incidentally found during routine screening. Preoperative imaging revealed lesions in the S4 and S5 liver segments, with postoperative confirmation of sdpHCC-ICC. He received hepatic arterial infusion chemotherapy (HAIC) and transcatheter arterial chemoembolization (TACE) combined with gemcitabine and oral S-1 over 26 months, with no recurrence observed. Case 2 describes a 48-year-old woman presenting with right upper abdominal pain. Preoperative imaging identified a lesion at the S6/7 and S8 junction, later confirmed as sdpHCC-ICC. Postoperative TACE was performed at 1.5 and 3 months, and lenvatinib was introduced at 3.5 months. She remained recurrence-free at the 21-month follow-up. While the precise pathogenesis of sdpHCC-ICC remains unclear, chronic HBV infection plays a pivotal role. Surgical resection remains the primary treatment, though prognosis is generally poor due to the ICC component. |
| format | Article |
| id | doaj-art-21301a6dd860480e9d2e932223318c68 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-21301a6dd860480e9d2e932223318c682025-08-20T03:20:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15074541507454Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature reviewPengcheng Wei0Pengcheng Wei1Pengcheng Wei2Nan Kang3Chen Lo4Chen Lo5Chen Lo6Yongjing Luo7Yongjing Luo8Yongjing Luo9Jie Gao10Jie Gao11Jie Gao12Jie Gao13Jiye Zhu14Jiye Zhu15Jiye Zhu16Jiye Zhu17Zhao Li18Zhao Li19Zhao Li20Zhao Li21Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, ChinaBeijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Peking University People’s Hospital, Beijing, ChinaPeking University Center of Liver Cancer Diagnosis and Treatment, Peking University People’s Hospital, Beijing, ChinaDepartment of Pathology, Peking University People’s Hospital, Beijing, ChinaDepartment of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, ChinaBeijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Peking University People’s Hospital, Beijing, ChinaPeking University Center of Liver Cancer Diagnosis and Treatment, Peking University People’s Hospital, Beijing, ChinaDepartment of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, ChinaBeijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Peking University People’s Hospital, Beijing, ChinaPeking University Center of Liver Cancer Diagnosis and Treatment, Peking University People’s Hospital, Beijing, ChinaDepartment of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, ChinaBeijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Peking University People’s Hospital, Beijing, ChinaPeking University Center of Liver Cancer Diagnosis and Treatment, Peking University People’s Hospital, Beijing, ChinaPeking University Institute of Organ Transplantation, Peking University People’s Hospital, Beijing, ChinaDepartment of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, ChinaBeijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Peking University People’s Hospital, Beijing, ChinaPeking University Center of Liver Cancer Diagnosis and Treatment, Peking University People’s Hospital, Beijing, ChinaPeking University Institute of Organ Transplantation, Peking University People’s Hospital, Beijing, ChinaDepartment of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, ChinaBeijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Peking University People’s Hospital, Beijing, ChinaPeking University Center of Liver Cancer Diagnosis and Treatment, Peking University People’s Hospital, Beijing, ChinaPeking University Institute of Organ Transplantation, Peking University People’s Hospital, Beijing, ChinaSimultaneous occurrence of primary hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is rare. We report two cases of synchronous double primary HCC and ICC (sdpHCC-ICC), both associated with chronic hepatitis B. Case 1 involves a 63-year-old man whose liver lesions were incidentally found during routine screening. Preoperative imaging revealed lesions in the S4 and S5 liver segments, with postoperative confirmation of sdpHCC-ICC. He received hepatic arterial infusion chemotherapy (HAIC) and transcatheter arterial chemoembolization (TACE) combined with gemcitabine and oral S-1 over 26 months, with no recurrence observed. Case 2 describes a 48-year-old woman presenting with right upper abdominal pain. Preoperative imaging identified a lesion at the S6/7 and S8 junction, later confirmed as sdpHCC-ICC. Postoperative TACE was performed at 1.5 and 3 months, and lenvatinib was introduced at 3.5 months. She remained recurrence-free at the 21-month follow-up. While the precise pathogenesis of sdpHCC-ICC remains unclear, chronic HBV infection plays a pivotal role. Surgical resection remains the primary treatment, though prognosis is generally poor due to the ICC component.https://www.frontiersin.org/articles/10.3389/fonc.2025.1507454/fulldouble primary hepatic cancerhepatocellular carcinomaintrahepatic cholangiocarcinomachronic liver diseasehepatitis B virus |
| spellingShingle | Pengcheng Wei Pengcheng Wei Pengcheng Wei Nan Kang Chen Lo Chen Lo Chen Lo Yongjing Luo Yongjing Luo Yongjing Luo Jie Gao Jie Gao Jie Gao Jie Gao Jiye Zhu Jiye Zhu Jiye Zhu Jiye Zhu Zhao Li Zhao Li Zhao Li Zhao Li Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review Frontiers in Oncology double primary hepatic cancer hepatocellular carcinoma intrahepatic cholangiocarcinoma chronic liver disease hepatitis B virus |
| title | Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review |
| title_full | Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review |
| title_fullStr | Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review |
| title_full_unstemmed | Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review |
| title_short | Synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis B: two case reports and literature review |
| title_sort | synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma in a single patient with chronic hepatitis b two case reports and literature review |
| topic | double primary hepatic cancer hepatocellular carcinoma intrahepatic cholangiocarcinoma chronic liver disease hepatitis B virus |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1507454/full |
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