The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice
Abstract The production of spermatozoa, a process known as spermatogenesis, is primarily controlled by follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-driven testosterone. LH acts on the Leydig cells, stimulating steroid production, predominantly testosterone, and activating critical...
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BMC
2025-01-01
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Online Access: | https://doi.org/10.1186/s12958-024-01333-4 |
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author | Sandro C. Esteves Peter Humaidan |
author_facet | Sandro C. Esteves Peter Humaidan |
author_sort | Sandro C. Esteves |
collection | DOAJ |
description | Abstract The production of spermatozoa, a process known as spermatogenesis, is primarily controlled by follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-driven testosterone. LH acts on the Leydig cells, stimulating steroid production, predominantly testosterone, and activating critical inter-related spermatogenesis regulatory pathways. Despite evidence that exogenous gonadotropins containing LH activity can effectively restore spermatogenesis in males with hypogonadotropic hypogonadism, the use of these drugs to treat other forms of male infertility is the subject of an ongoing debate. In this review, we delve into the molecular properties and functions of LH activity in spermatogenesis regulation and explore available preparations for therapeutic use. We also examine the evidence regarding the effectiveness of LH-containing drugs in treating specific male infertility conditions and identify the main areas for future research. Our review highlights the critical role of LH in spermatogenesis and emphasizes the potential of LH-containing drugs in treating male infertility. However, further research is required to completely elucidate the mechanisms underlying the effects of LH activity on sperm production and to establish the most effective dosages and treatment durations. |
format | Article |
id | doaj-art-2128337efe9b465a8b437e2354aebe74 |
institution | Kabale University |
issn | 1477-7827 |
language | English |
publishDate | 2025-01-01 |
publisher | BMC |
record_format | Article |
series | Reproductive Biology and Endocrinology |
spelling | doaj-art-2128337efe9b465a8b437e2354aebe742025-01-19T12:43:30ZengBMCReproductive Biology and Endocrinology1477-78272025-01-0123S112010.1186/s12958-024-01333-4The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practiceSandro C. Esteves0Peter Humaidan1ANDROFERT, Andrology and Human Reproduction ClinicDepartment of Clinical Medicine, Faculty of Health, Aarhus UniversityAbstract The production of spermatozoa, a process known as spermatogenesis, is primarily controlled by follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-driven testosterone. LH acts on the Leydig cells, stimulating steroid production, predominantly testosterone, and activating critical inter-related spermatogenesis regulatory pathways. Despite evidence that exogenous gonadotropins containing LH activity can effectively restore spermatogenesis in males with hypogonadotropic hypogonadism, the use of these drugs to treat other forms of male infertility is the subject of an ongoing debate. In this review, we delve into the molecular properties and functions of LH activity in spermatogenesis regulation and explore available preparations for therapeutic use. We also examine the evidence regarding the effectiveness of LH-containing drugs in treating specific male infertility conditions and identify the main areas for future research. Our review highlights the critical role of LH in spermatogenesis and emphasizes the potential of LH-containing drugs in treating male infertility. However, further research is required to completely elucidate the mechanisms underlying the effects of LH activity on sperm production and to establish the most effective dosages and treatment durations.https://doi.org/10.1186/s12958-024-01333-4Male infertilityHypogonadismHormonal therapyLuteinizing hormoneHuman chorionic gonadotropinSpermatogenesis |
spellingShingle | Sandro C. Esteves Peter Humaidan The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice Reproductive Biology and Endocrinology Male infertility Hypogonadism Hormonal therapy Luteinizing hormone Human chorionic gonadotropin Spermatogenesis |
title | The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice |
title_full | The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice |
title_fullStr | The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice |
title_full_unstemmed | The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice |
title_short | The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice |
title_sort | role of luteinizing hormone activity in spermatogenesis from physiology to clinical practice |
topic | Male infertility Hypogonadism Hormonal therapy Luteinizing hormone Human chorionic gonadotropin Spermatogenesis |
url | https://doi.org/10.1186/s12958-024-01333-4 |
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