The effect of Lactobacillus acidophilus as a probiotic against Pseudomonas aeruginosa growth and biofilm formation
The emergence of antibiotic-resistant biofilm producing microorganisms such as Pseudomonas aeruginosa has pushed efforts to find safe alternatives to antibiotics; such as probiotics. Lactobacilli are one of these promising probiotics, with reported antibacterial and anti-biofilm activity against m...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ResearchersLinks, Ltd
2019-08-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://nrmj.journals.ekb.eg/article_44951_909e72678031008d9b3d77d6de8484e8.pdf |
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| Summary: | The emergence of antibiotic-resistant biofilm producing microorganisms such as Pseudomonas aeruginosa
has pushed efforts to find safe alternatives to antibiotics; such as probiotics. Lactobacilli are one of these
promising probiotics, with reported antibacterial and anti-biofilm activity against many different pathogenic
microorganisms. This study aimed to study the potential antibacterial and anti-biofilm effect of Lactobacillus
acidophilus ATCC 4356, against the growth and biofilm formation of pathogenic P. aeruginosa. Cell free
supernatant of L. acidophilus was tested to inhibit the growth; biofilm formation, and on preformed biofilms by
35 different clinical strains of P. aeruginosa, using agar well diffusion and microtitre plate assays. L. acidophilus
ATCC 4356 recorded powerful growth inhibition against 88.6% of the P. aeruginosa strains. Moreover; it
significantly inhibited biofilm formation of the strains by 68.52%, and removed already preformed biofilms with
43.8 % activity. Finally; L. acidophilus showed a potent inhibitory potential against the growth and biofilm
formation by P. aeruginosa strains, thus could be used as a powerful probiotic for the bio-control of infections
caused by antibiotic resistant and biofilm producing P. aeruginosa. |
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| ISSN: | 2537-0286 2537-0294 |