Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters
Lentinan (LNT) was found to reduce the aerosol transmission rate between golden hamsters from 100% (9/9) to 44.4% (4/9). The viral loads in the respiratory system, including the nasal turbinate, trachea, and lung, were significantly reduced in the infected golden hamsters that received LNT treatment...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/3/597 |
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| author | Cheng Zhang Jiaming Li Huan Cui Yifei Jin Zhaoliang Chen Lei Zhang Sihui Song Bing Lu Zhongyi Wang Zhendong Guo |
| author_facet | Cheng Zhang Jiaming Li Huan Cui Yifei Jin Zhaoliang Chen Lei Zhang Sihui Song Bing Lu Zhongyi Wang Zhendong Guo |
| author_sort | Cheng Zhang |
| collection | DOAJ |
| description | Lentinan (LNT) was found to reduce the aerosol transmission rate between golden hamsters from 100% (9/9) to 44.4% (4/9). The viral loads in the respiratory system, including the nasal turbinate, trachea, and lung, were significantly reduced in the infected golden hamsters that received LNT treatment. Furthermore, the amount of exhaled virus aerosols in hamsters treated with LNT was significantly lower than that in untreated hamsters throughout the entire disease progression. In detail, the amounts of virus-laden particles with aerodynamic diameters less than 5 µm exhibited a significant decreasing trend following LNT treatment. Moreover, the detection rate of infectious SARS-CoV-2 in each stage of the Anderson-6 sampler exhibited a decreasing trend following LNT treatment post-infection. In summary, our findings indicate that LNT therapy represents a promising therapeutic candidate for the treatment of COVID-19 patients. Meanwhile, during the course of treatment, LNT has the potential to reduce viral infectivity in affected individuals. |
| format | Article |
| id | doaj-art-211cbef59f934f88922829398ad73c78 |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-211cbef59f934f88922829398ad73c782025-08-20T03:43:20ZengMDPI AGMicroorganisms2076-26072025-03-0113359710.3390/microorganisms13030597Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden HamstersCheng Zhang0Jiaming Li1Huan Cui2Yifei Jin3Zhaoliang Chen4Lei Zhang5Sihui Song6Bing Lu7Zhongyi Wang8Zhendong Guo9Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, ChinaBeijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, ChinaBeijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, ChinaBeijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, ChinaBeijing Institute of Biotechnology, 20 Dongdajie Road, Beijing 100071, ChinaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, ChinaLentinan (LNT) was found to reduce the aerosol transmission rate between golden hamsters from 100% (9/9) to 44.4% (4/9). The viral loads in the respiratory system, including the nasal turbinate, trachea, and lung, were significantly reduced in the infected golden hamsters that received LNT treatment. Furthermore, the amount of exhaled virus aerosols in hamsters treated with LNT was significantly lower than that in untreated hamsters throughout the entire disease progression. In detail, the amounts of virus-laden particles with aerodynamic diameters less than 5 µm exhibited a significant decreasing trend following LNT treatment. Moreover, the detection rate of infectious SARS-CoV-2 in each stage of the Anderson-6 sampler exhibited a decreasing trend following LNT treatment post-infection. In summary, our findings indicate that LNT therapy represents a promising therapeutic candidate for the treatment of COVID-19 patients. Meanwhile, during the course of treatment, LNT has the potential to reduce viral infectivity in affected individuals.https://www.mdpi.com/2076-2607/13/3/597lentinanaerosol transmissibilityexhaled virus aerosolsaerodynamic diameters |
| spellingShingle | Cheng Zhang Jiaming Li Huan Cui Yifei Jin Zhaoliang Chen Lei Zhang Sihui Song Bing Lu Zhongyi Wang Zhendong Guo Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters Microorganisms lentinan aerosol transmissibility exhaled virus aerosols aerodynamic diameters |
| title | Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters |
| title_full | Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters |
| title_fullStr | Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters |
| title_full_unstemmed | Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters |
| title_short | Lentinan Reduces Transmission Efficiency of COVID-19 by Changing Aerodynamic Characteristic of Exhaled SARS-CoV-2 Aerosols in Golden Hamsters |
| title_sort | lentinan reduces transmission efficiency of covid 19 by changing aerodynamic characteristic of exhaled sars cov 2 aerosols in golden hamsters |
| topic | lentinan aerosol transmissibility exhaled virus aerosols aerodynamic diameters |
| url | https://www.mdpi.com/2076-2607/13/3/597 |
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