Recent advances in TAM mechanisms in lung diseases
Abstract TYRO3, MERTK, and AXL receptor tyrosine kinases, collectively known as TAM receptors, play a vital role in maintaining lung tissue homeostasis by regulating integrity and self-renewal. These receptors activate signalling pathways that inhibit apoptosis, promote cell proliferation and differ...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06398-2 |
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| author | Jiaqi Ban Jiayi Qian Chi Zhang Jun Li |
| author_facet | Jiaqi Ban Jiayi Qian Chi Zhang Jun Li |
| author_sort | Jiaqi Ban |
| collection | DOAJ |
| description | Abstract TYRO3, MERTK, and AXL receptor tyrosine kinases, collectively known as TAM receptors, play a vital role in maintaining lung tissue homeostasis by regulating integrity and self-renewal. These receptors activate signalling pathways that inhibit apoptosis, promote cell proliferation and differentiation, mediate cell adhesion and migration, and perform other essential biological functions. Additionally, TAM receptors are implicated in mechanisms that suppress anti-tumor immunity and confer resistance to immune checkpoint inhibitors. Disruption of the homeostatic balances can lead to pathological conditions such as lung inflammation, fibrosis, or tumors. Recent studies highlight their significant role in COVID-19-induced lung injury. However, the exact mechanisms by which TAM receptors contribute to lung diseases remain unclear. This article reviews the potential mechanisms of TAM receptor involvement in disease progression, focusing on lung inflammation, fibrosis, cancer, and COVID-19-induced lung injury. It also explores future research aspects and the therapeutic potentials of targeting TAM receptors, providing a theoretical foundation for understanding lung disease mechanisms and identifying treatment targets. |
| format | Article |
| id | doaj-art-21115ea9dacd4799ade4ed66acaa4887 |
| institution | OA Journals |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-21115ea9dacd4799ade4ed66acaa48872025-08-20T02:30:18ZengBMCJournal of Translational Medicine1479-58762025-04-0123111810.1186/s12967-025-06398-2Recent advances in TAM mechanisms in lung diseasesJiaqi Ban0Jiayi Qian1Chi Zhang2Jun Li3School of Public Health, The key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical UniversitySchool of Public Health, The key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical UniversitySchool of Clinical Medicine, Ministry of Education, Guizhou Medical UniversitySchool of Public Health, The key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical UniversityAbstract TYRO3, MERTK, and AXL receptor tyrosine kinases, collectively known as TAM receptors, play a vital role in maintaining lung tissue homeostasis by regulating integrity and self-renewal. These receptors activate signalling pathways that inhibit apoptosis, promote cell proliferation and differentiation, mediate cell adhesion and migration, and perform other essential biological functions. Additionally, TAM receptors are implicated in mechanisms that suppress anti-tumor immunity and confer resistance to immune checkpoint inhibitors. Disruption of the homeostatic balances can lead to pathological conditions such as lung inflammation, fibrosis, or tumors. Recent studies highlight their significant role in COVID-19-induced lung injury. However, the exact mechanisms by which TAM receptors contribute to lung diseases remain unclear. This article reviews the potential mechanisms of TAM receptor involvement in disease progression, focusing on lung inflammation, fibrosis, cancer, and COVID-19-induced lung injury. It also explores future research aspects and the therapeutic potentials of targeting TAM receptors, providing a theoretical foundation for understanding lung disease mechanisms and identifying treatment targets.https://doi.org/10.1186/s12967-025-06398-2Lung diseasesTYRO3MERTKAXLCOVID-19 |
| spellingShingle | Jiaqi Ban Jiayi Qian Chi Zhang Jun Li Recent advances in TAM mechanisms in lung diseases Journal of Translational Medicine Lung diseases TYRO3 MERTK AXL COVID-19 |
| title | Recent advances in TAM mechanisms in lung diseases |
| title_full | Recent advances in TAM mechanisms in lung diseases |
| title_fullStr | Recent advances in TAM mechanisms in lung diseases |
| title_full_unstemmed | Recent advances in TAM mechanisms in lung diseases |
| title_short | Recent advances in TAM mechanisms in lung diseases |
| title_sort | recent advances in tam mechanisms in lung diseases |
| topic | Lung diseases TYRO3 MERTK AXL COVID-19 |
| url | https://doi.org/10.1186/s12967-025-06398-2 |
| work_keys_str_mv | AT jiaqiban recentadvancesintammechanismsinlungdiseases AT jiayiqian recentadvancesintammechanismsinlungdiseases AT chizhang recentadvancesintammechanismsinlungdiseases AT junli recentadvancesintammechanismsinlungdiseases |