Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens

Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens

Summary: Antibiotic resistance is a major threat to human health and new drugs are urgently needed. Ideally, these drugs should have several cellular targets in pathogens, decreasing the risk of resistance development. We show here that two natural ribosomally synthesized lasso peptides (LPs), svice...

Full description

Saved in:
Bibliographic Details
Main Authors: Abdelhakim Boudrioua, Benjamin Baëtz, Solenn Desmadril, Christophe Goulard, Anne-Claire Groo, Carine Lombard, Sabrina Gueulle, Marie Marugan, Aurélie Malzert-Fréon, Axel Hartke, Yanyan Li, Caroline Giraud
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:iScience
Subjects:
Drugs
Biochemistry
Peptides
Medical Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225001828
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items