Advances in in vivo magnetic resonance spectroscopy for metabolic disorders
Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Imaging (MRI) yield valuable metabolic information in a non-invasive way. The current mini review addresses current practice and recent advances in metabolic research, specifically in the field of obesity, insulin resistance and diabetes....
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1578333/full |
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| author | Yuliya Kupriyanova Yuliya Kupriyanova Vera Schrauwen-Hinderling Vera Schrauwen-Hinderling Vera Schrauwen-Hinderling |
| author_facet | Yuliya Kupriyanova Yuliya Kupriyanova Vera Schrauwen-Hinderling Vera Schrauwen-Hinderling Vera Schrauwen-Hinderling |
| author_sort | Yuliya Kupriyanova |
| collection | DOAJ |
| description | Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Imaging (MRI) yield valuable metabolic information in a non-invasive way. The current mini review addresses current practice and recent advances in metabolic research, specifically in the field of obesity, insulin resistance and diabetes. The potential application of MRS to investigate lipid and glycogen stores, as well as energy metabolism are reviewed and novel methods to extract more detailed information on fatty acid composition or newly detectable metabolites such as acetylcarnitine or nicotinamide adenosine dinucleotide (NAD+) and NADH are discussed. These advances are based on optimization of post-processing or on the application of new schemes for spectral editing to suppress unwanted signal. The advantage of MRS is that it gives real-time dynamic information and therefore, metabolism can be investigated during physiological challenges, such as exercise, food intake or immediate drug action. Due to its non-invasive nature, repeated measurements are possible with MRS, to monitor treatments and interventions and also organs that are not easily accessible for biopsies, such as the liver or the heart can be probed by MRS. When investing in further methodological development, new applications will arise, advancing our understanding of metabolic disease and giving us tools to identify successful treatment and prevention strategies in individuals at risk. |
| format | Article |
| id | doaj-art-210fa7bbd1bf4ba8ac33b5d67b80b55a |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-210fa7bbd1bf4ba8ac33b5d67b80b55a2025-08-20T02:39:41ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.15783331578333Advances in in vivo magnetic resonance spectroscopy for metabolic disordersYuliya Kupriyanova0Yuliya Kupriyanova1Vera Schrauwen-Hinderling2Vera Schrauwen-Hinderling3Vera Schrauwen-Hinderling4Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, GermanyGerman Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, GermanyInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, GermanyGerman Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, GermanyDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, NetherlandsMagnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Imaging (MRI) yield valuable metabolic information in a non-invasive way. The current mini review addresses current practice and recent advances in metabolic research, specifically in the field of obesity, insulin resistance and diabetes. The potential application of MRS to investigate lipid and glycogen stores, as well as energy metabolism are reviewed and novel methods to extract more detailed information on fatty acid composition or newly detectable metabolites such as acetylcarnitine or nicotinamide adenosine dinucleotide (NAD+) and NADH are discussed. These advances are based on optimization of post-processing or on the application of new schemes for spectral editing to suppress unwanted signal. The advantage of MRS is that it gives real-time dynamic information and therefore, metabolism can be investigated during physiological challenges, such as exercise, food intake or immediate drug action. Due to its non-invasive nature, repeated measurements are possible with MRS, to monitor treatments and interventions and also organs that are not easily accessible for biopsies, such as the liver or the heart can be probed by MRS. When investing in further methodological development, new applications will arise, advancing our understanding of metabolic disease and giving us tools to identify successful treatment and prevention strategies in individuals at risk.https://www.frontiersin.org/articles/10.3389/fendo.2025.1578333/fullmagnetic resonance spectroscopymetabolic healthdiabeteslipid metabolismglycogenmitochondrial function |
| spellingShingle | Yuliya Kupriyanova Yuliya Kupriyanova Vera Schrauwen-Hinderling Vera Schrauwen-Hinderling Vera Schrauwen-Hinderling Advances in in vivo magnetic resonance spectroscopy for metabolic disorders Frontiers in Endocrinology magnetic resonance spectroscopy metabolic health diabetes lipid metabolism glycogen mitochondrial function |
| title | Advances in in vivo magnetic resonance spectroscopy for metabolic disorders |
| title_full | Advances in in vivo magnetic resonance spectroscopy for metabolic disorders |
| title_fullStr | Advances in in vivo magnetic resonance spectroscopy for metabolic disorders |
| title_full_unstemmed | Advances in in vivo magnetic resonance spectroscopy for metabolic disorders |
| title_short | Advances in in vivo magnetic resonance spectroscopy for metabolic disorders |
| title_sort | advances in in vivo magnetic resonance spectroscopy for metabolic disorders |
| topic | magnetic resonance spectroscopy metabolic health diabetes lipid metabolism glycogen mitochondrial function |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1578333/full |
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