Coenzyme Q10 supplementation in adult-onset focal segmental glomerulosclerosis caused by the Chinese common pathogenic variant c.737G > A (p.Ser246Asn) in the COQ8B gene

Coenzyme Q10 supplementation in adult-onset focal segmental glomerulosclerosis caused by the Chinese common pathogenic variant c.737G > A (p.Ser246Asn) in the COQ8B gene

COQ8B nephropathy, a mitochondrial disorder caused by mutations in the COQ8B gene, is a major pediatric genetic focal segmental glomerulosclerosis (GFSGS) etiology and stands out as one of the few treatable forms with good response to coenzyme Q10 (CoQ10) supplementation. As the diagnosis and clinic...

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Bibliographic Details
Main Authors: Shi Jin, Yiqin Shi, Pan Lin, Hong Liu, Xialian Xu, Xuantong Dai, Gengru Jiang, Xiaoqiang Ding, Fujun Lin
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Focal segmental glomerulosclerosis
podocyte
COQ8B
coenzyme Q10
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2501204
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