In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry
Synthesis and characterization of well-defined amphiphilic block copolymers containing poly(2-ethyl-2-oxazoline) as hydrophilic block and poly(ε-caprolactone) or poly(L-lactide) as hydrophobic block is achieved by copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. The clickable pre...
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| Format: | Article |
| Language: | English |
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Budapest University of Technology and Economics
2018-02-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0008460&mi=cd |
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| author | S. Gulyuz U. U. Ozkose P. Kocak D. Telci O. Yilmaz M. A. Tasdelen |
| author_facet | S. Gulyuz U. U. Ozkose P. Kocak D. Telci O. Yilmaz M. A. Tasdelen |
| author_sort | S. Gulyuz |
| collection | DOAJ |
| description | Synthesis and characterization of well-defined amphiphilic block copolymers containing poly(2-ethyl-2-oxazoline) as hydrophilic block and poly(ε-caprolactone) or poly(L-lactide) as hydrophobic block is achieved by copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. The clickable precursors, α-alkyne-functionalized poly(ε-caprolactone) and poly(L-lactide) and ω-azido-functionalized poly(2-ethyl-2-oxazoline) are simply prepared and joined using copper sulfate/ascorbic acid catalyst system at room temperature. The structures of precursors and amphiphilic block copolymers are characterized by spectroscopic, chromatographic and thermal analyses. The cytotoxic activities of resulting amphiphilic block copolymers and their precursors are investigated in the prostate epithelial and cancer cells under in-vitro conditions. The treatment of the healthy prostate epithelial cell line PNT1A reveals that no significant cytotoxicity, whereas some significant toxic effects on the prostate cancer cell lines are observed. |
| format | Article |
| id | doaj-art-210477088dfe454cb70a4ddace85e576 |
| institution | Kabale University |
| issn | 1788-618X |
| language | English |
| publishDate | 2018-02-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-210477088dfe454cb70a4ddace85e5762025-08-20T03:32:55ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2018-02-0112214615810.3144/expresspolymlett.2018.13In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistryS. GulyuzU. U. OzkoseP. KocakD. TelciO. YilmazM. A. TasdelenSynthesis and characterization of well-defined amphiphilic block copolymers containing poly(2-ethyl-2-oxazoline) as hydrophilic block and poly(ε-caprolactone) or poly(L-lactide) as hydrophobic block is achieved by copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. The clickable precursors, α-alkyne-functionalized poly(ε-caprolactone) and poly(L-lactide) and ω-azido-functionalized poly(2-ethyl-2-oxazoline) are simply prepared and joined using copper sulfate/ascorbic acid catalyst system at room temperature. The structures of precursors and amphiphilic block copolymers are characterized by spectroscopic, chromatographic and thermal analyses. The cytotoxic activities of resulting amphiphilic block copolymers and their precursors are investigated in the prostate epithelial and cancer cells under in-vitro conditions. The treatment of the healthy prostate epithelial cell line PNT1A reveals that no significant cytotoxicity, whereas some significant toxic effects on the prostate cancer cell lines are observed.http://www.expresspolymlett.com/letolt.php?file=EPL-0008460&mi=cdPolymer synthesis, molecular eamphiphilic block copolymerscopper-catalyzed azide-alkyne cytotoxic effectpolyoxazolines |
| spellingShingle | S. Gulyuz U. U. Ozkose P. Kocak D. Telci O. Yilmaz M. A. Tasdelen In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry eXPRESS Polymer Letters Polymer synthesis, molecular e amphiphilic block copolymers copper-catalyzed azide-alkyne cytotoxic effect polyoxazolines |
| title | In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry |
| title_full | In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry |
| title_fullStr | In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry |
| title_full_unstemmed | In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry |
| title_short | In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry |
| title_sort | in vitro cytotoxic activities of poly 2 ethyl 2 oxazoline based amphiphilic block copolymers prepared by cuaac click chemistry |
| topic | Polymer synthesis, molecular e amphiphilic block copolymers copper-catalyzed azide-alkyne cytotoxic effect polyoxazolines |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0008460&mi=cd |
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