Common Ɣ-chain cytokine receptors as functional phenotype markers of PD-1and TIM-3-positive T cells in multiple myeloma

Common Ɣ-chain cytokine receptors as functional phenotype markers of PD-1and TIM-3-positive T cells in multiple myeloma

T cells expressing checkpoint receptors PD-1, TIM-3 etc., are potential targets for monoclonal antibody immunotherapy in multiple myeloma (MM). However, checkpoint expressing T cell compartment includes different subsets, and their dysregulation following anti-checkpoint therapy can lead to the deve...

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Bibliographic Details
Main Authors: E. V. Batorov, V. A. Aristova, G. Yu. Ushakova, S. A. Sizikova, V. V. Denisova, E. Ya. Shevela, A. A. Ostanin, E. R. Chernykh
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2023-02-01
Series:Сибирский онкологический журнал
Subjects:
multiple mueloma
pd-1
tim-3
cd25
cd122
eomes
t cell exhaustion
regulatory t cells
Online Access:https://www.siboncoj.ru/jour/article/view/2430
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