Genetic factors for breast carcinogenesis
Breast cancer is a multifactorial genenetic disease in which oncogenes derived from normal cellular genes intervene, which constitute positive signals of cellular proliferation and tumour suppressor genes and represent negative signals of cells multiplication and differentiation. Although these alte...
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| Format: | Article |
| Language: | Spanish |
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Universidad de las Ciencias Médicas de Cienfuegos
2016-12-01
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| Series: | Revista Finlay |
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| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/470 |
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| author | Pedro Enrique Miguel-Soca Ivis Argüelles González Marisol Peña González |
| author_facet | Pedro Enrique Miguel-Soca Ivis Argüelles González Marisol Peña González |
| author_sort | Pedro Enrique Miguel-Soca |
| collection | DOAJ |
| description | Breast cancer is a multifactorial genenetic disease in which oncogenes derived from normal cellular genes intervene, which constitute positive signals of cellular proliferation and tumour suppressor genes and represent negative signals of cells multiplication and differentiation. Although these alterations which affect germinal cells produce inherited cancers, in most of the cases somatic cell genes are affected. To the susceptibility of cancer due to genes as BRCA1 and BCRA2, the effect of factors associated to environment, life style and toxic habits are added, these determine a complex interrelation genes-environment which imply an activation of oncogenes and inactivation of tumour suppressors. The objective of this review in to offer an updated view about the main genes implied in breast carcinogenesis. The topic is controversial y currently deeply investigated. |
| format | Article |
| id | doaj-art-20fee26501714d63916cfccb7f91e12c |
| institution | Kabale University |
| issn | 2221-2434 |
| language | Spanish |
| publishDate | 2016-12-01 |
| publisher | Universidad de las Ciencias Médicas de Cienfuegos |
| record_format | Article |
| series | Revista Finlay |
| spelling | doaj-art-20fee26501714d63916cfccb7f91e12c2025-01-30T21:21:58ZspaUniversidad de las Ciencias Médicas de CienfuegosRevista Finlay2221-24342016-12-0164299316272Genetic factors for breast carcinogenesisPedro Enrique Miguel-Soca0Ivis Argüelles González1Marisol Peña González2Universidad de Ciencias Médicas. Holguín.Universidad de Ciencias Médicas. Holguín.Universidad de Ciencias Médicas. Holguín.Breast cancer is a multifactorial genenetic disease in which oncogenes derived from normal cellular genes intervene, which constitute positive signals of cellular proliferation and tumour suppressor genes and represent negative signals of cells multiplication and differentiation. Although these alterations which affect germinal cells produce inherited cancers, in most of the cases somatic cell genes are affected. To the susceptibility of cancer due to genes as BRCA1 and BCRA2, the effect of factors associated to environment, life style and toxic habits are added, these determine a complex interrelation genes-environment which imply an activation of oncogenes and inactivation of tumour suppressors. The objective of this review in to offer an updated view about the main genes implied in breast carcinogenesis. The topic is controversial y currently deeply investigated.https://revfinlay.sld.cu/index.php/finlay/article/view/470neoplasias de la mamaenfermedades genéticas congénitasgen brca1gen brca2carcinogénesis |
| spellingShingle | Pedro Enrique Miguel-Soca Ivis Argüelles González Marisol Peña González Genetic factors for breast carcinogenesis Revista Finlay neoplasias de la mama enfermedades genéticas congénitas gen brca1 gen brca2 carcinogénesis |
| title | Genetic factors for breast carcinogenesis |
| title_full | Genetic factors for breast carcinogenesis |
| title_fullStr | Genetic factors for breast carcinogenesis |
| title_full_unstemmed | Genetic factors for breast carcinogenesis |
| title_short | Genetic factors for breast carcinogenesis |
| title_sort | genetic factors for breast carcinogenesis |
| topic | neoplasias de la mama enfermedades genéticas congénitas gen brca1 gen brca2 carcinogénesis |
| url | https://revfinlay.sld.cu/index.php/finlay/article/view/470 |
| work_keys_str_mv | AT pedroenriquemiguelsoca geneticfactorsforbreastcarcinogenesis AT ivisarguellesgonzalez geneticfactorsforbreastcarcinogenesis AT marisolpenagonzalez geneticfactorsforbreastcarcinogenesis |