Single-cell transcriptomic and m6A methylation analyses reveal platelet-mediated immune regulatory mechanisms in sepsis

Single-cell transcriptomic and m6A methylation analyses reveal platelet-mediated immune regulatory mechanisms in sepsis

ObjectiveSepsis is a systemic inflammatory response syndrome triggered by infection, characterized by high clinical heterogeneity and complex immunopathological mechanisms. Immune dysregulation plays a central role in its progression. This study aims to investigate the compositional changes of immun...

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Bibliographic Details
Main Authors: Weiwei Qian, Yuanyuan Liu, Xinyang Zhao, Yuxin Dong, Jian Zhou, Songtao Shou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
sepsis
single-cell transcriptomics
m6A methylation
platelets
RPA1
APP-CD74 signaling axis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607732/full
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