Deacetylation of nuclear AIF provides a braking mechanism for caspase-independent chromatinolysis and necrotic brain injury

Deacetylation of nuclear AIF provides a braking mechanism for caspase-independent chromatinolysis and necrotic brain injury

Abstract Programmed necrosis involves three consecutive stages: initiation, propagation, and execution. The initiation of necrosis has been widely studied, but due to the diversity and pleiotropy of the initiating pathways, it is difficult to identify ideal targets for necrosis inhibition from upstr...

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Main Authors: Chen Hu, Jichuan Geng, Peipei Shan, Tongqing Zhang, Zhuqing Zhang, Xiaoyu Zhang, Menghan Lin, Xiaoxia Zhang, Dong Chang, Baokun He, Deshui Jia, Mary Zhang, Chuangui Wang, Shengping Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08255-w
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