Mesoporous carbon from Murraya koenigii: A promising anticancer, anti-inflammatory, and antidiabetic agent
Murraya koenigii (curry leaves), a member of the Rutaceae family, is a well-known aromatic plant with culinary and medicinal properties. This study aimed to produce a mesoporous carbon-based material (MCM) from Murraya koenigii (M. koenigii) leaves and evaluate its potential as an anticancer, anti-i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Next Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949822825002266 |
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| author | K. Saravanan P. Seenuvasakumaran A. Ubaithulla Baig P.N. Sudha M. Ayyanar M. Sivakami R. Balaji P. Abarna C. Jenipher K. Ravichandran N. Jabena Begum |
| author_facet | K. Saravanan P. Seenuvasakumaran A. Ubaithulla Baig P.N. Sudha M. Ayyanar M. Sivakami R. Balaji P. Abarna C. Jenipher K. Ravichandran N. Jabena Begum |
| author_sort | K. Saravanan |
| collection | DOAJ |
| description | Murraya koenigii (curry leaves), a member of the Rutaceae family, is a well-known aromatic plant with culinary and medicinal properties. This study aimed to produce a mesoporous carbon-based material (MCM) from Murraya koenigii (M. koenigii) leaves and evaluate its potential as an anticancer, anti-inflammatory, and antidiabetic agent. Leaves contain essential chemical components, including carboxylic alkaloids, phenolics, flavonoids, carbohydrates, proteins, fibers, metal ions, minerals, vitamins, and antioxidants. Despite the effectiveness of plants as a source of bioactive agents, their leaves are considered solid waste. To manage and utilize this waste effectively, the leaves were processed to produce MCM. The material was characterized using various techniques, and its antioxidant, antidiabetic, anti-inflammatory, and anticancer properties were assessed in vitro. The results demonstrated that MCM exhibited significant antioxidant activity, inhibited key enzymes involved in diabetes, reduced the expression of inflammatory markers, and displayed cytotoxicity against cancer cell lines while remaining nontoxic to normal cells. These findings suggest that MCM derived from M koenigii leaves is a promising natural remedy for the treatment of cancer, diabetes, and inflammation, offering a sustainable approach to managing these chronic health issues while effectively utilizing agricultural waste. |
| format | Article |
| id | doaj-art-20f2b71526fa459b843538717945eead |
| institution | OA Journals |
| issn | 2949-8228 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Materials |
| spelling | doaj-art-20f2b71526fa459b843538717945eead2025-08-20T02:31:00ZengElsevierNext Materials2949-82282025-07-01810070810.1016/j.nxmate.2025.100708Mesoporous carbon from Murraya koenigii: A promising anticancer, anti-inflammatory, and antidiabetic agentK. Saravanan0P. Seenuvasakumaran1A. Ubaithulla Baig2P.N. Sudha3M. Ayyanar4M. Sivakami5R. Balaji6P. Abarna7C. Jenipher8K. Ravichandran9N. Jabena Begum10PG & Research Department of Physics, Muthurangam Government Arts College (A) (Affiliated to Thiruvalluvar University), Vellore, Tamil Nadu 632002, IndiaDepartment of Physics, Government Arts & Science College, Tirupattur, Tamil Nadu 635901, IndiaDepartment of Science and Humanities, C. Abdul Hakeem College of Engineering and Technology, Melvisharam, Ranipet, Tamil Nadu 632 509, IndiaDepartment of Physiology, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India; Corresponding authors.PG & Research Department of Botany, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Thanjavur, Tamil Nadu 613 503, IndiaDepartment of Physics, H.H. The Rajah’s College (A), Pudukkottai, Tamil Nadu 622 001, IndiaPG & Research Department of Physics, Muthurangam Government Arts College (A) (Affiliated to Thiruvalluvar University), Vellore, Tamil Nadu 632002, IndiaPG & Research Department of Microbiology, D.K.M. College for Women (Autonomous), Vellore, Tamil Nadu 632 001, IndiaPG & Research Department of Botany, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Thanjavur, Tamil Nadu 613 503, IndiaPG & Research Department of Physics, Thanthai Hans Roever College (Affiliated to Bharathidasan University), Perambalur, Tamil Nadu 621 220, IndiaDepartment of Physics, D.K.M. College for Women (Autonomous), (Affiliated to Thiruvalluvar University), Vellore, Tamil Nadu 632 001, India; Corresponding authors.Murraya koenigii (curry leaves), a member of the Rutaceae family, is a well-known aromatic plant with culinary and medicinal properties. This study aimed to produce a mesoporous carbon-based material (MCM) from Murraya koenigii (M. koenigii) leaves and evaluate its potential as an anticancer, anti-inflammatory, and antidiabetic agent. Leaves contain essential chemical components, including carboxylic alkaloids, phenolics, flavonoids, carbohydrates, proteins, fibers, metal ions, minerals, vitamins, and antioxidants. Despite the effectiveness of plants as a source of bioactive agents, their leaves are considered solid waste. To manage and utilize this waste effectively, the leaves were processed to produce MCM. The material was characterized using various techniques, and its antioxidant, antidiabetic, anti-inflammatory, and anticancer properties were assessed in vitro. The results demonstrated that MCM exhibited significant antioxidant activity, inhibited key enzymes involved in diabetes, reduced the expression of inflammatory markers, and displayed cytotoxicity against cancer cell lines while remaining nontoxic to normal cells. These findings suggest that MCM derived from M koenigii leaves is a promising natural remedy for the treatment of cancer, diabetes, and inflammation, offering a sustainable approach to managing these chronic health issues while effectively utilizing agricultural waste.http://www.sciencedirect.com/science/article/pii/S2949822825002266Mesoporous carbonMurraya koenigiiAnticancerAnti-inflammatoryAntidiabetic agent |
| spellingShingle | K. Saravanan P. Seenuvasakumaran A. Ubaithulla Baig P.N. Sudha M. Ayyanar M. Sivakami R. Balaji P. Abarna C. Jenipher K. Ravichandran N. Jabena Begum Mesoporous carbon from Murraya koenigii: A promising anticancer, anti-inflammatory, and antidiabetic agent Next Materials Mesoporous carbon Murraya koenigii Anticancer Anti-inflammatory Antidiabetic agent |
| title | Mesoporous carbon from Murraya koenigii: A promising anticancer, anti-inflammatory, and antidiabetic agent |
| title_full | Mesoporous carbon from Murraya koenigii: A promising anticancer, anti-inflammatory, and antidiabetic agent |
| title_fullStr | Mesoporous carbon from Murraya koenigii: A promising anticancer, anti-inflammatory, and antidiabetic agent |
| title_full_unstemmed | Mesoporous carbon from Murraya koenigii: A promising anticancer, anti-inflammatory, and antidiabetic agent |
| title_short | Mesoporous carbon from Murraya koenigii: A promising anticancer, anti-inflammatory, and antidiabetic agent |
| title_sort | mesoporous carbon from murraya koenigii a promising anticancer anti inflammatory and antidiabetic agent |
| topic | Mesoporous carbon Murraya koenigii Anticancer Anti-inflammatory Antidiabetic agent |
| url | http://www.sciencedirect.com/science/article/pii/S2949822825002266 |
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