Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial Activity
In the present work, a series of new 5-substituted-3-(4-arylimino)-1-[5-mercapto(1,3,4-oxadiazolyl)]-methyl-indol-2-one (4a-g) have been synthesized by heterocyclization of 5-substituted-3-(4-arylimino)-2-oxo-1-indole acetylhyrazide (3a-g) on treatment with CS2 in ethanolic KOH. The compound 4a was...
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| Format: | Article |
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| Language: | English |
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University of Tehran
2008-09-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31895_981b4487122b372fdfd27ff42d00fa12.pdf |
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| description | In the present work, a series of new 5-substituted-3-(4-arylimino)-1-[5-mercapto(1,3,4-oxadiazolyl)]-methyl-indol-2-one (4a-g) have been synthesized by heterocyclization of 5-substituted-3-(4-arylimino)-2-oxo-1-indole acetylhyrazide (3a-g) on treatment with CS2 in ethanolic KOH. The compound 4a was characterized by its elemental analysis, IR, 1HNMR and Mass Spectroscopy. The synthesized compounds (4a-g) were evaluated for in vitro antibacterial activity and antifungal activity against various strains of bacteria and fungi. |
| format | Article |
| id | doaj-art-20ebfa9d94924c1d807a8850858185ea |
| institution | OA Journals |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 2008-09-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-20ebfa9d94924c1d807a8850858185ea2025-08-20T02:25:51ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69142008-09-0119331895Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial ActivityIn the present work, a series of new 5-substituted-3-(4-arylimino)-1-[5-mercapto(1,3,4-oxadiazolyl)]-methyl-indol-2-one (4a-g) have been synthesized by heterocyclization of 5-substituted-3-(4-arylimino)-2-oxo-1-indole acetylhyrazide (3a-g) on treatment with CS2 in ethanolic KOH. The compound 4a was characterized by its elemental analysis, IR, 1HNMR and Mass Spectroscopy. The synthesized compounds (4a-g) were evaluated for in vitro antibacterial activity and antifungal activity against various strains of bacteria and fungi.https://jsciences.ut.ac.ir/article_31895_981b4487122b372fdfd27ff42d00fa12.pdf |
| spellingShingle | Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial Activity Journal of Sciences, Islamic Republic of Iran |
| title | Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial Activity |
| title_full | Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial Activity |
| title_fullStr | Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial Activity |
| title_full_unstemmed | Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial Activity |
| title_short | Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial Activity |
| title_sort | synthesis and pharmacological evaluation of some novel isatin derivatives for antimicrobial activity |
| url | https://jsciences.ut.ac.ir/article_31895_981b4487122b372fdfd27ff42d00fa12.pdf |