Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort
Purpose The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows a...
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e059434.full |
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| author | Thorarinn Gislason Torben Sigsgaard Vivi Schlünssen Joachim Heinrich Jesús Martínez-Moratalla Øistein Svanes Mathias Holm Bertil Forsberg Dan Norbäck Rain Jogi Kjell Torén Deborah Jarvis Magnus Ekström Adrian Lowe Caroline J Lodge Michael Abramson Shyamali Dharmage Kathrine Pape Cecilie Svanes Gita Mishra Caroline Lodge Lyle Gurrin Bruce Thompson Eva Lindberg Christer Janson Simone Accordini Ane Johannessen Bryndis Benediktsdottir Karl Franklin Andrei Malinovschi Anna Oudin Francisco Gómez Real José Luis Sánchez-Ramos Lennart Bråbäck Torgeir Storaas Shanshan Xu Julia Dratva John Holloway Jorunn Kirkeleit Christine Cramer Gro Tjalvin Anne Mette Lund Würtz Randi Jacobsen Bertelsen Oskar Jõgi Signe Timm Francisco Javier Callejas Raúl Godoy Trude Duelien Skorge Christine Drengenes Nils Oskar Jõgi Maryia Khomich Toril Mørkve Knudsen Ingrid Kuiper Juan Pablo López-Cervantes Marianne Lønnebotn Shokouh Makvandi-Nejad Antonio Pérez Anders Røsland Rajesh Shigdel Svein Magne Skulstad Kai Triebner Hilde Vindenes Jose Luis Sanchez Jose Maldonado David Martino Jennifer Perret Lucia Calciano William Horsnell Susanne Krauss-Etchmann |
| author_facet | Thorarinn Gislason Torben Sigsgaard Vivi Schlünssen Joachim Heinrich Jesús Martínez-Moratalla Øistein Svanes Mathias Holm Bertil Forsberg Dan Norbäck Rain Jogi Kjell Torén Deborah Jarvis Magnus Ekström Adrian Lowe Caroline J Lodge Michael Abramson Shyamali Dharmage Kathrine Pape Cecilie Svanes Gita Mishra Caroline Lodge Lyle Gurrin Bruce Thompson Eva Lindberg Christer Janson Simone Accordini Ane Johannessen Bryndis Benediktsdottir Karl Franklin Andrei Malinovschi Anna Oudin Francisco Gómez Real José Luis Sánchez-Ramos Lennart Bråbäck Torgeir Storaas Shanshan Xu Julia Dratva John Holloway Jorunn Kirkeleit Christine Cramer Gro Tjalvin Anne Mette Lund Würtz Randi Jacobsen Bertelsen Oskar Jõgi Signe Timm Francisco Javier Callejas Raúl Godoy Trude Duelien Skorge Christine Drengenes Nils Oskar Jõgi Maryia Khomich Toril Mørkve Knudsen Ingrid Kuiper Juan Pablo López-Cervantes Marianne Lønnebotn Shokouh Makvandi-Nejad Antonio Pérez Anders Røsland Rajesh Shigdel Svein Magne Skulstad Kai Triebner Hilde Vindenes Jose Luis Sanchez Jose Maldonado David Martino Jennifer Perret Lucia Calciano William Horsnell Susanne Krauss-Etchmann |
| collection | DOAJ |
| description | Purpose The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations.Participants RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014–17 in a questionnaire study (N=8818, age 18–53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20–44 years old, at 8–10 years intervals. Study protocols are harmonised across generations.Findings to date Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father’s exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father’s exposures to offspring health and disease through impact on offspring DNA methylation.Future plans Follow-up is planned at 5–8 years intervals, first in 2021–2023. Linkage with health registries contributes to follow-up of the cohort. |
| format | Article |
| id | doaj-art-20e82eee7d01405ea9727de2df1bd26f |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-20e82eee7d01405ea9727de2df1bd26f2025-01-27T22:05:09ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-059434Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort Thorarinn Gislason0Torben Sigsgaard1Vivi Schlünssen2Joachim Heinrich3Jesús Martínez-Moratalla4Øistein Svanes5Mathias Holm6Bertil Forsberg7Dan Norbäck8Rain Jogi9Kjell Torén10Deborah JarvisMagnus Ekström11Adrian LoweCaroline J Lodge12Michael Abramson13Shyamali Dharmage14Kathrine PapeCecilie Svanes15Gita Mishra16Caroline Lodge17Lyle Gurrin18Bruce Thompson19Eva Lindberg20Christer Janson21Simone Accordini22Ane Johannessen23Bryndis Benediktsdottir24Karl Franklin25Andrei Malinovschi26Anna Oudin27Francisco Gómez Real28José Luis Sánchez-Ramos29Lennart Bråbäck30Torgeir StoraasShanshan Xu31Julia DratvaJohn HollowayJorunn Kirkeleit32Christine Cramer33Gro Tjalvin34Anne Mette Lund Würtz35Randi Jacobsen Bertelsen36Oskar Jõgi37Signe Timm38Francisco Javier Callejas39Raúl GodoyTrude Duelien SkorgeChristine Drengenes40Nils Oskar Jõgi41Maryia KhomichToril Mørkve KnudsenIngrid KuiperJuan Pablo López-Cervantes42Marianne LønnebotnShokouh Makvandi-NejadAntonio PérezAnders RøslandRajesh ShigdelSvein Magne SkulstadKai TriebnerHilde VindenesJose Luis Sanchez43Jose MaldonadoDavid MartinoJennifer Perret44Lucia Calciano45William Horsnell46Susanne Krauss-EtchmannLandspitali University Hospital, Reykjavik, IcelandDepartment of Public Health, Research Unit for Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, DenmarkDepartment of Public Health, Research Unit for Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark14 Department of psychology, Institute and Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University Munich, Munchen, GermanyServicio de Neumología, Complejo Hospitalario Universitario de Albacete, Albacete, Spain23 Department of Occupational Medicine, Haukeland University Hospital, Bergen, NorwayDepartment of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Goteborg, Swedenprofessor27 Department of Medical Sciences, Uppsala University, Uppsala, SwedenLung Clinic, Tartu University Hospital, Tartu, EstoniaOccupational and Environmental Medicine, School of Public Health and Community Medicine, University of Gothenburg Institute of Medicine, Goteborg, SwedenFaculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund, SwedenCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, AustraliaMonash University, Melbourne, AustraliaAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, AustraliaDepartment of Global Public Health and Primary Care, Centre for International Health, University of Bergen Faculty of Medicine and Dentistry, Bergen, NorwaySchool of Public Health, The University of Queensland, Saint Lucia, Queensland, AustraliaAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, AustraliaAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, AustraliaHealth Sciences, Swinburne University of Technology, Melbourne, Victoria, Australia1 Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, SwedenDepartment of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, SwedenUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy2Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, NorwayFaculty of Medicine, University of Iceland, Reykjavik, Iceland5 Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umea, SwedenMedical Sciences, Uppsala University, Uppsala, SwedenDepartment of Public Health and Clinical Medicine, Umeå University, Umea, SwedenDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Nursing, University of Huelva, Huelva, SpainSection of Sustainable Health, Department of Public Health and Clinical Medicine, Umeå Universitet, Umeå, SwedenDepartment of Pharmacy, Beijing Tongren Hospital, Beijing, ChinaDepartment of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway5Department of Public Health, Research Unit for Work, Environment and Health, Danish Ramazzini Centre, Aarhus University, DK-8000 Aarhus C, DenmarkDepartment of Occupational Medicine, Haukeland University Hospital, Bergen, Norway1Netherlands Organization for Applied Scientific Research (TNO), The NetherlandsDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Oncology, Lillebaelt Hospital-University Hospital of Southern Denmark, Vejle, DenmarkDepartment of Respiratory Medicine, Albacete University Hospital Complex, Albacete, Spain2 Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, NorwayDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, SwedenDepartment of Global Public Health and Primary Care, Centre for International Health, University of Bergen Faculty of Medicine and Dentistry, Bergen, NorwayHospital Universitari Vall Hebrón, Barcelona, SpainAllergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, AustraliaEpidemiological Department, Azienda Zero, Padova, ItalyDepartment of Pathology, University of Cape Town, Cape Town, South AfricaPurpose The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations.Participants RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014–17 in a questionnaire study (N=8818, age 18–53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20–44 years old, at 8–10 years intervals. Study protocols are harmonised across generations.Findings to date Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father’s exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father’s exposures to offspring health and disease through impact on offspring DNA methylation.Future plans Follow-up is planned at 5–8 years intervals, first in 2021–2023. Linkage with health registries contributes to follow-up of the cohort.https://bmjopen.bmj.com/content/12/6/e059434.full |
| spellingShingle | Thorarinn Gislason Torben Sigsgaard Vivi Schlünssen Joachim Heinrich Jesús Martínez-Moratalla Øistein Svanes Mathias Holm Bertil Forsberg Dan Norbäck Rain Jogi Kjell Torén Deborah Jarvis Magnus Ekström Adrian Lowe Caroline J Lodge Michael Abramson Shyamali Dharmage Kathrine Pape Cecilie Svanes Gita Mishra Caroline Lodge Lyle Gurrin Bruce Thompson Eva Lindberg Christer Janson Simone Accordini Ane Johannessen Bryndis Benediktsdottir Karl Franklin Andrei Malinovschi Anna Oudin Francisco Gómez Real José Luis Sánchez-Ramos Lennart Bråbäck Torgeir Storaas Shanshan Xu Julia Dratva John Holloway Jorunn Kirkeleit Christine Cramer Gro Tjalvin Anne Mette Lund Würtz Randi Jacobsen Bertelsen Oskar Jõgi Signe Timm Francisco Javier Callejas Raúl Godoy Trude Duelien Skorge Christine Drengenes Nils Oskar Jõgi Maryia Khomich Toril Mørkve Knudsen Ingrid Kuiper Juan Pablo López-Cervantes Marianne Lønnebotn Shokouh Makvandi-Nejad Antonio Pérez Anders Røsland Rajesh Shigdel Svein Magne Skulstad Kai Triebner Hilde Vindenes Jose Luis Sanchez Jose Maldonado David Martino Jennifer Perret Lucia Calciano William Horsnell Susanne Krauss-Etchmann Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort BMJ Open |
| title | Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
| title_full | Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
| title_fullStr | Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
| title_full_unstemmed | Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
| title_short | Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort |
| title_sort | cohort profile the multigeneration respiratory health in northern europe spain and australia rhinessa cohort |
| url | https://bmjopen.bmj.com/content/12/6/e059434.full |
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