RP-HPLC Determination of Three Anti-Hyperlipidemic Drugs in Spiked Human Plasma and in Dosage Forms
Sensitive, simple and accurate high performance liquid chromatographic (HPLC) methods for the determination of atorvastatin (AT), fluvastatin (FL) and pravastatin (PV) have been developed. The proposed methods involve the use of a 150 mmx4.6 mm Zorbax Extend-C18 column (5 μm particle size) and diffe...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/376948 |
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| _version_ | 1849306870322298880 |
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| author | Ola. M. Abdallah |
| author_facet | Ola. M. Abdallah |
| author_sort | Ola. M. Abdallah |
| collection | DOAJ |
| description | Sensitive, simple and accurate high performance liquid chromatographic (HPLC) methods for the determination of atorvastatin (AT), fluvastatin (FL) and pravastatin (PV) have been developed. The proposed methods involve the use of a 150 mmx4.6 mm Zorbax Extend-C18 column (5 μm particle size) and different chromatographic conditions for the separation of the three statins. Linearity range was 5-40, 5-30 and 10-60 μg mL-1 for AT, FL and PV respectively. The developed methods proved to be successful in the determination of all studied drugs in spiked human plasma samples. |
| format | Article |
| id | doaj-art-20e7bd1dd0e542d4bd67d4c7df39b193 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-20e7bd1dd0e542d4bd67d4c7df39b1932025-08-20T03:54:57ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018275376110.1155/2011/376948RP-HPLC Determination of Three Anti-Hyperlipidemic Drugs in Spiked Human Plasma and in Dosage FormsOla. M. Abdallah0Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), El- Wahat Road, 6th October City, EgyptSensitive, simple and accurate high performance liquid chromatographic (HPLC) methods for the determination of atorvastatin (AT), fluvastatin (FL) and pravastatin (PV) have been developed. The proposed methods involve the use of a 150 mmx4.6 mm Zorbax Extend-C18 column (5 μm particle size) and different chromatographic conditions for the separation of the three statins. Linearity range was 5-40, 5-30 and 10-60 μg mL-1 for AT, FL and PV respectively. The developed methods proved to be successful in the determination of all studied drugs in spiked human plasma samples.http://dx.doi.org/10.1155/2011/376948 |
| spellingShingle | Ola. M. Abdallah RP-HPLC Determination of Three Anti-Hyperlipidemic Drugs in Spiked Human Plasma and in Dosage Forms E-Journal of Chemistry |
| title | RP-HPLC Determination of Three Anti-Hyperlipidemic Drugs in Spiked Human Plasma and in Dosage Forms |
| title_full | RP-HPLC Determination of Three Anti-Hyperlipidemic Drugs in Spiked Human Plasma and in Dosage Forms |
| title_fullStr | RP-HPLC Determination of Three Anti-Hyperlipidemic Drugs in Spiked Human Plasma and in Dosage Forms |
| title_full_unstemmed | RP-HPLC Determination of Three Anti-Hyperlipidemic Drugs in Spiked Human Plasma and in Dosage Forms |
| title_short | RP-HPLC Determination of Three Anti-Hyperlipidemic Drugs in Spiked Human Plasma and in Dosage Forms |
| title_sort | rp hplc determination of three anti hyperlipidemic drugs in spiked human plasma and in dosage forms |
| url | http://dx.doi.org/10.1155/2011/376948 |
| work_keys_str_mv | AT olamabdallah rphplcdeterminationofthreeantihyperlipidemicdrugsinspikedhumanplasmaandindosageforms |