Protective Effects of Thymol with Hormonal, Antiinflammatory and Antioxidant Pathways in Lipopolysaccharide-Induced Ovarian Damage in Rats
This study investigated the protective effects of thymol on LPS-induced ovarian damage. Female Wistar albino rats were divided into five groups (n=35, group=7): control, solvent, LPS, thymol, and LPS+thymol. At the end of the study, hormone (E2 and AMH), oxidative stress (MDA, GSH, GSH-Px and catala...
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| Language: | English |
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Atatürk University
2025-04-01
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| Series: | Veterinary Sciences and Practices |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/4126447 |
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| author | Gökhan Uyanık İshak Gökçek |
| author_facet | Gökhan Uyanık İshak Gökçek |
| author_sort | Gökhan Uyanık |
| collection | DOAJ |
| description | This study investigated the protective effects of thymol on LPS-induced ovarian damage. Female Wistar albino rats were divided into five groups (n=35, group=7): control, solvent, LPS, thymol, and LPS+thymol. At the end of the study, hormone (E2 and AMH), oxidative stress (MDA, GSH, GSH-Px and catalase), and inflammatory cytokine (TNF-α and IL-6) analyses were performed in the samples taken from the animals. Ovary and body weights were also measured. Lipopolysaccharide treatment caused decreases in E2 AMH, GSH, GSH-Px and catalase levels but increased MDA, TNF-α and IL-6 levels. In the Lps+thymol group, thymol administration caused increases in E2, AMH, GSH, GSH-Px and catalase levels and decreased MDA, TNF-α and IL-6 levels. In conclusion, thymol administration positively affected Lps-induced hormonal, oxidative stress and inflammatory changes via antioxidant and anti-inflammatory mechanisms. However, it is thought that the long-term effects of thymol need to be demonstrated, especially by further molecular mechanisms. |
| format | Article |
| id | doaj-art-20e7276fdfa34be9a7ab9a640d2ff877 |
| institution | OA Journals |
| issn | 2822-3608 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Atatürk University |
| record_format | Article |
| series | Veterinary Sciences and Practices |
| spelling | doaj-art-20e7276fdfa34be9a7ab9a640d2ff8772025-08-20T01:47:40ZengAtatürk UniversityVeterinary Sciences and Practices2822-36082025-04-012011710.17094/vetsci.152909955Protective Effects of Thymol with Hormonal, Antiinflammatory and Antioxidant Pathways in Lipopolysaccharide-Induced Ovarian Damage in RatsGökhan Uyanık0https://orcid.org/0000-0003-4488-3055İshak Gökçek1https://orcid.org/0000-0002-0590-6405HATAY MUSTAFA KEMAL UNIVERSITY, FACULTY OF VETERINARY MEDICINE, VETERINARY MEDICINE PR.Hatay Mustafa Kemal Üniversitesi Veteriner FakültesiThis study investigated the protective effects of thymol on LPS-induced ovarian damage. Female Wistar albino rats were divided into five groups (n=35, group=7): control, solvent, LPS, thymol, and LPS+thymol. At the end of the study, hormone (E2 and AMH), oxidative stress (MDA, GSH, GSH-Px and catalase), and inflammatory cytokine (TNF-α and IL-6) analyses were performed in the samples taken from the animals. Ovary and body weights were also measured. Lipopolysaccharide treatment caused decreases in E2 AMH, GSH, GSH-Px and catalase levels but increased MDA, TNF-α and IL-6 levels. In the Lps+thymol group, thymol administration caused increases in E2, AMH, GSH, GSH-Px and catalase levels and decreased MDA, TNF-α and IL-6 levels. In conclusion, thymol administration positively affected Lps-induced hormonal, oxidative stress and inflammatory changes via antioxidant and anti-inflammatory mechanisms. However, it is thought that the long-term effects of thymol need to be demonstrated, especially by further molecular mechanisms.https://dergipark.org.tr/tr/download/article-file/4126447lpsthymolovarian reserveinflammationoxidant-antioxidant statuslpstimolovaryum rezervyangıoksidan-antioksidan durum |
| spellingShingle | Gökhan Uyanık İshak Gökçek Protective Effects of Thymol with Hormonal, Antiinflammatory and Antioxidant Pathways in Lipopolysaccharide-Induced Ovarian Damage in Rats Veterinary Sciences and Practices lps thymol ovarian reserve inflammation oxidant-antioxidant status lps timol ovaryum rezerv yangı oksidan-antioksidan durum |
| title | Protective Effects of Thymol with Hormonal, Antiinflammatory and Antioxidant Pathways in Lipopolysaccharide-Induced Ovarian Damage in Rats |
| title_full | Protective Effects of Thymol with Hormonal, Antiinflammatory and Antioxidant Pathways in Lipopolysaccharide-Induced Ovarian Damage in Rats |
| title_fullStr | Protective Effects of Thymol with Hormonal, Antiinflammatory and Antioxidant Pathways in Lipopolysaccharide-Induced Ovarian Damage in Rats |
| title_full_unstemmed | Protective Effects of Thymol with Hormonal, Antiinflammatory and Antioxidant Pathways in Lipopolysaccharide-Induced Ovarian Damage in Rats |
| title_short | Protective Effects of Thymol with Hormonal, Antiinflammatory and Antioxidant Pathways in Lipopolysaccharide-Induced Ovarian Damage in Rats |
| title_sort | protective effects of thymol with hormonal antiinflammatory and antioxidant pathways in lipopolysaccharide induced ovarian damage in rats |
| topic | lps thymol ovarian reserve inflammation oxidant-antioxidant status lps timol ovaryum rezerv yangı oksidan-antioksidan durum |
| url | https://dergipark.org.tr/tr/download/article-file/4126447 |
| work_keys_str_mv | AT gokhanuyanık protectiveeffectsofthymolwithhormonalantiinflammatoryandantioxidantpathwaysinlipopolysaccharideinducedovariandamageinrats AT ishakgokcek protectiveeffectsofthymolwithhormonalantiinflammatoryandantioxidantpathwaysinlipopolysaccharideinducedovariandamageinrats |