PlastiCRISPR: Genome Editing-Based Plastic Waste Management with Implications in Polyethylene Terephthalate (PET) Degradation
Plastic pollution has become a significant environmental issue worldwide, with global plastic production expected to reach 1800 million tons by 2050. One of the most commonly used plastics in the world is polyethylene terephthalate (PET), a synthetic polymer that is extremely durable but difficult t...
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| Format: | Article |
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MDPI AG
2025-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/5/684 |
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| author | Puja Palit Maya Minkara Maisha Abida Safa Marwa Chandrima Sen Ayan Roy Md Ridoan Pasha Paulraj Selvakumar Mosae Ayan Saha Jannatul Ferdoush |
| author_facet | Puja Palit Maya Minkara Maisha Abida Safa Marwa Chandrima Sen Ayan Roy Md Ridoan Pasha Paulraj Selvakumar Mosae Ayan Saha Jannatul Ferdoush |
| author_sort | Puja Palit |
| collection | DOAJ |
| description | Plastic pollution has become a significant environmental issue worldwide, with global plastic production expected to reach 1800 million tons by 2050. One of the most commonly used plastics in the world is polyethylene terephthalate (PET), a synthetic polymer that is extremely durable but difficult to degrade. Thus, PET is dangerous to human health. To address this crisis, innovative approaches are being developed, including genome editing technologies. One of the recently advanced genome editing technologies is PlastiCRISPR, a novel concept that applies CRISPR-based genome editing to transform plastic waste management. PlastiCRISPR utilizes microorganisms to degrade plastic, generating valuable bioproducts like biofuels and biochemicals. Thus, this technology offers a sustainable solution because of its simple design, adequacy, and low cost, which can be integrated into existing waste management systems. Importantly, this review focuses on the PlastiCRISPR-based management of PET because it could drastically lower plastic waste, sustain natural resources by decreasing the requirement for plastic production, minimize energy intake, etc. Overall, this review provides an overview of the principles, applications, challenges, and future prospects of PlastiCRISPR in combating plastic pollution and shaping a more sustainable future. |
| format | Article |
| id | doaj-art-20e465ab057845b490786ed3c2df0c8f |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-20e465ab057845b490786ed3c2df0c8f2025-08-20T01:56:14ZengMDPI AGBiomolecules2218-273X2025-05-0115568410.3390/biom15050684PlastiCRISPR: Genome Editing-Based Plastic Waste Management with Implications in Polyethylene Terephthalate (PET) DegradationPuja Palit0Maya Minkara1Maisha Abida2Safa Marwa3Chandrima Sen4Ayan Roy5Md Ridoan Pasha6Paulraj Selvakumar Mosae7Ayan Saha8Jannatul Ferdoush9Department of Biological Sciences, Asian University for Women, Chittagong 4000, BangladeshDepartment of Biology, Geology, and Environmental Science, University of Tennessee at Chattanooga, 615 McCallie Ave, Chattanooga, TN 37403, USADepartment of Biological Sciences, Asian University for Women, Chittagong 4000, BangladeshDepartment of Biological Sciences, Asian University for Women, Chittagong 4000, BangladeshDepartment of Biological Sciences, Asian University for Women, Chittagong 4000, BangladeshDepartment of Biological Sciences, Asian University for Women, Chittagong 4000, BangladeshDepartment of Physiology, Biochemistry, and Pharmacology, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, BangladeshDepartment of Environmental Sciences, Asian University for Women, Chittagong 4000, BangladeshDepartment of Biological Sciences, Asian University for Women, Chittagong 4000, BangladeshDepartment of Biology, Geology, and Environmental Science, University of Tennessee at Chattanooga, 615 McCallie Ave, Chattanooga, TN 37403, USAPlastic pollution has become a significant environmental issue worldwide, with global plastic production expected to reach 1800 million tons by 2050. One of the most commonly used plastics in the world is polyethylene terephthalate (PET), a synthetic polymer that is extremely durable but difficult to degrade. Thus, PET is dangerous to human health. To address this crisis, innovative approaches are being developed, including genome editing technologies. One of the recently advanced genome editing technologies is PlastiCRISPR, a novel concept that applies CRISPR-based genome editing to transform plastic waste management. PlastiCRISPR utilizes microorganisms to degrade plastic, generating valuable bioproducts like biofuels and biochemicals. Thus, this technology offers a sustainable solution because of its simple design, adequacy, and low cost, which can be integrated into existing waste management systems. Importantly, this review focuses on the PlastiCRISPR-based management of PET because it could drastically lower plastic waste, sustain natural resources by decreasing the requirement for plastic production, minimize energy intake, etc. Overall, this review provides an overview of the principles, applications, challenges, and future prospects of PlastiCRISPR in combating plastic pollution and shaping a more sustainable future.https://www.mdpi.com/2218-273X/15/5/684PlastiCRISPRgenome editingCRISPR-Cas9microorganismsbiodegradationbioplastic production |
| spellingShingle | Puja Palit Maya Minkara Maisha Abida Safa Marwa Chandrima Sen Ayan Roy Md Ridoan Pasha Paulraj Selvakumar Mosae Ayan Saha Jannatul Ferdoush PlastiCRISPR: Genome Editing-Based Plastic Waste Management with Implications in Polyethylene Terephthalate (PET) Degradation Biomolecules PlastiCRISPR genome editing CRISPR-Cas9 microorganisms biodegradation bioplastic production |
| title | PlastiCRISPR: Genome Editing-Based Plastic Waste Management with Implications in Polyethylene Terephthalate (PET) Degradation |
| title_full | PlastiCRISPR: Genome Editing-Based Plastic Waste Management with Implications in Polyethylene Terephthalate (PET) Degradation |
| title_fullStr | PlastiCRISPR: Genome Editing-Based Plastic Waste Management with Implications in Polyethylene Terephthalate (PET) Degradation |
| title_full_unstemmed | PlastiCRISPR: Genome Editing-Based Plastic Waste Management with Implications in Polyethylene Terephthalate (PET) Degradation |
| title_short | PlastiCRISPR: Genome Editing-Based Plastic Waste Management with Implications in Polyethylene Terephthalate (PET) Degradation |
| title_sort | plasticrispr genome editing based plastic waste management with implications in polyethylene terephthalate pet degradation |
| topic | PlastiCRISPR genome editing CRISPR-Cas9 microorganisms biodegradation bioplastic production |
| url | https://www.mdpi.com/2218-273X/15/5/684 |
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