Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapy
Heart transplantation is the «gold standard» of treatment severe heart failure. Patient survival after heart transplantation has improved dramatically since the availability of calcineurin inhibitor (CNIs). However, nephrotoxicity of CNIs has been largely responsible for the progressive developmen...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2018-09-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/914 |
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| author | N. N. Koloskova E. A. Nikitina V. M. Zakharevich I. I. Muminov V. S. Cvan V. N. Poptsov R. L. Ahmadzai D. A. Izotov A. O. Shevchenko |
| author_facet | N. N. Koloskova E. A. Nikitina V. M. Zakharevich I. I. Muminov V. S. Cvan V. N. Poptsov R. L. Ahmadzai D. A. Izotov A. O. Shevchenko |
| author_sort | N. N. Koloskova |
| collection | DOAJ |
| description | Heart transplantation is the «gold standard» of treatment severe heart failure. Patient survival after heart transplantation has improved dramatically since the availability of calcineurin inhibitor (CNIs). However, nephrotoxicity of CNIs has been largely responsible for the progressive development of renal dysfunction and reduces long-term patient survival. Use mTOR inhibitor in immunosuppressive therapy may improve renal function when everolimus is administered associated with a progressive reduction of CNIs. The purpose of our report is to demonstrate the successful case of conversion of the recipient after heart transplantation to everolimus and to evaluate the effectiveness of this drug during the observation year after heart transplantation. |
| format | Article |
| id | doaj-art-20e0463f890042049d270e6bbcd4f6a0 |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2018-09-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-20e0463f890042049d270e6bbcd4f6a02025-08-20T03:21:06ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912018-09-01203707410.15825/1995-1191-2018-3-70-74723Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapyN. N. Koloskova0E. A. Nikitina1V. M. Zakharevich2I. I. Muminov3V. S. Cvan4V. N. Poptsov5R. L. Ahmadzai6D. A. Izotov7A. O. Shevchenko8V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University)Heart transplantation is the «gold standard» of treatment severe heart failure. Patient survival after heart transplantation has improved dramatically since the availability of calcineurin inhibitor (CNIs). However, nephrotoxicity of CNIs has been largely responsible for the progressive development of renal dysfunction and reduces long-term patient survival. Use mTOR inhibitor in immunosuppressive therapy may improve renal function when everolimus is administered associated with a progressive reduction of CNIs. The purpose of our report is to demonstrate the successful case of conversion of the recipient after heart transplantation to everolimus and to evaluate the effectiveness of this drug during the observation year after heart transplantation.https://journal.transpl.ru/vtio/article/view/914heart transplantationimmunosuppressive therapynephrotoxicity of calcineurin inhibitorrenal dysfunctionеverolimusmtor inhibitor |
| spellingShingle | N. N. Koloskova E. A. Nikitina V. M. Zakharevich I. I. Muminov V. S. Cvan V. N. Poptsov R. L. Ahmadzai D. A. Izotov A. O. Shevchenko Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapy Вестник трансплантологии и искусственных органов heart transplantation immunosuppressive therapy nephrotoxicity of calcineurin inhibitor renal dysfunction еverolimus mtor inhibitor |
| title | Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapy |
| title_full | Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapy |
| title_fullStr | Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapy |
| title_full_unstemmed | Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapy |
| title_short | Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapy |
| title_sort | conversion to everolimus to preserve kidney function in a heart transplant recipient a personalized approach of immunos uppressive therapy |
| topic | heart transplantation immunosuppressive therapy nephrotoxicity of calcineurin inhibitor renal dysfunction еverolimus mtor inhibitor |
| url | https://journal.transpl.ru/vtio/article/view/914 |
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