Colistin-resistance and carbapenemase-producing among carbapenem-resistance E. coli and K. pneumoniae
Introduction: Carbapenemase-producing Enterobacterales (CPE) is one of the causes of community health-threatening, most common in Escherichia coli and Klebsiella pneumoniae. CPE has appeared in many countries, especially developing ones, but it has not been recognized in routine antibiograms. Also...
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| Format: | Article |
| Language: | Spanish |
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ECIMED
2024-07-01
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| Series: | Revista Cubana de Medicina Militar |
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| Online Access: | https://revmedmilitar.sld.cu/index.php/mil/article/view/60109 |
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| author | Ngá»c BÃch Trần Phu Thien Truong Loc Tran Mai Nguyen Dang Ngoc Tran Thao Thi Ngoc Nguyen Phuong Thi Nam Nguyen Tuan Anh Dang Van Thi Hue Tran Dat Quoc Ngo |
| author_facet | Ngá»c BÃch Trần Phu Thien Truong Loc Tran Mai Nguyen Dang Ngoc Tran Thao Thi Ngoc Nguyen Phuong Thi Nam Nguyen Tuan Anh Dang Van Thi Hue Tran Dat Quoc Ngo |
| author_sort | Ngá»c BÃch Trần |
| collection | DOAJ |
| description | Introduction: Carbapenemase-producing Enterobacterales (CPE) is one of the causes of community health-threatening, most common in Escherichia coli and Klebsiella pneumoniae. CPE has appeared in many countries, especially developing ones, but it has not been recognized in routine antibiograms. Also, assessing colistin susceptibility is a significant obstacle for both diagnostic and epidemiological because of technical difficulties. There is rare data about CPE and colistin-resistant Enterobacterales.
Objectives: Determine the prevalence of producing carbapenemase and colistin-resistance among K. pneumoniae and E. coli resistant to carbapenems.
Methods: In a cross-sectional survey, 129 K. pneumoniae and 31 E. coli strains, which demonstrated carbapenem resistance, were collected from inpatients at Cho Ray Hospital over a three-month period. Carbapenemase production was detected using the modified carbapenem inactivation method and EDTA-modified carbapenem inactivation method, and colistin resistance was detected using the broth microdilution method according to CLSI M100S34.
Results: Of 160 participants' strains, 80% of carbapenemase-producing K. pneumoniae and E. coli were detected; among these, Metallo beta-lactamase-producing was taken 69,5%. Of 31 colistin-resistant, 30 were K. pneumoniae, and only 1 E. coli was detected that was resistant to colistin.
Conclusion: Among participants' strains, carbapenemase-producing prevalence was very high. There were signs of a widespread extensively drug-resistant K. pneumoniae. Most of E. coliwas susceptible to colistin.
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| format | Article |
| id | doaj-art-20dfbcff07bf406e9d693f2168b71b93 |
| institution | Kabale University |
| issn | 1561-3046 |
| language | Spanish |
| publishDate | 2024-07-01 |
| publisher | ECIMED |
| record_format | Article |
| series | Revista Cubana de Medicina Militar |
| spelling | doaj-art-20dfbcff07bf406e9d693f2168b71b932025-01-10T19:01:06ZspaECIMEDRevista Cubana de Medicina Militar1561-30462024-07-015331013Colistin-resistance and carbapenemase-producing among carbapenem-resistance E. coli and K. pneumoniaeNgá»c BÃch Trần0https://orcid.org/0000-0002-2255-6398Phu Thien Truong1https://orcid.org/0000-0003-0868-2811Loc Tran Mai Nguyen2https://orcid.org/0000-0003-3232-3587Dang Ngoc Tran3https://orcid.org/0000-0002-5287-0265Thao Thi Ngoc Nguyen4https://orcid.org/0009-0004-1295-401XPhuong Thi Nam Nguyen5https://orcid.org/0009-0002-5305-4726Tuan Anh Dang6https://orcid.org/0009-0008-1677-2650Van Thi Hue Tran7https://orcid.org/0009-0007-0677-2553Dat Quoc Ngo8https://orcid.org/0000-0003-1461-0216University of Medical and Pharmacy at Ho Chi MinhUniversity of Medical and Pharmacy at Ho Chi MinhUniversity of Medical and Pharmacy at Ho Chi MinhUniversity of Medical and Pharmacy at Ho Chi MinhCho Ray HospitalCho Ray HospitalCho Ray HospitalUniversity of Medical and Pharmacy at Ho Chi MinhUniversity of Medical and Pharmacy at Ho Chi MinhIntroduction: Carbapenemase-producing Enterobacterales (CPE) is one of the causes of community health-threatening, most common in Escherichia coli and Klebsiella pneumoniae. CPE has appeared in many countries, especially developing ones, but it has not been recognized in routine antibiograms. Also, assessing colistin susceptibility is a significant obstacle for both diagnostic and epidemiological because of technical difficulties. There is rare data about CPE and colistin-resistant Enterobacterales. Objectives: Determine the prevalence of producing carbapenemase and colistin-resistance among K. pneumoniae and E. coli resistant to carbapenems. Methods: In a cross-sectional survey, 129 K. pneumoniae and 31 E. coli strains, which demonstrated carbapenem resistance, were collected from inpatients at Cho Ray Hospital over a three-month period. Carbapenemase production was detected using the modified carbapenem inactivation method and EDTA-modified carbapenem inactivation method, and colistin resistance was detected using the broth microdilution method according to CLSI M100S34. Results: Of 160 participants' strains, 80% of carbapenemase-producing K. pneumoniae and E. coli were detected; among these, Metallo beta-lactamase-producing was taken 69,5%. Of 31 colistin-resistant, 30 were K. pneumoniae, and only 1 E. coli was detected that was resistant to colistin. Conclusion: Among participants' strains, carbapenemase-producing prevalence was very high. There were signs of a widespread extensively drug-resistant K. pneumoniae. Most of E. coliwas susceptible to colistin. https://revmedmilitar.sld.cu/index.php/mil/article/view/60109Klebsiella pneumoniaeEscherichia colicarbapenemasecolistinpolymyxin Edrug resistance |
| spellingShingle | Ngá»c BÃch Trần Phu Thien Truong Loc Tran Mai Nguyen Dang Ngoc Tran Thao Thi Ngoc Nguyen Phuong Thi Nam Nguyen Tuan Anh Dang Van Thi Hue Tran Dat Quoc Ngo Colistin-resistance and carbapenemase-producing among carbapenem-resistance E. coli and K. pneumoniae Revista Cubana de Medicina Militar Klebsiella pneumoniae Escherichia coli carbapenemase colistin polymyxin E drug resistance |
| title | Colistin-resistance and carbapenemase-producing among carbapenem-resistance E. coli and K. pneumoniae |
| title_full | Colistin-resistance and carbapenemase-producing among carbapenem-resistance E. coli and K. pneumoniae |
| title_fullStr | Colistin-resistance and carbapenemase-producing among carbapenem-resistance E. coli and K. pneumoniae |
| title_full_unstemmed | Colistin-resistance and carbapenemase-producing among carbapenem-resistance E. coli and K. pneumoniae |
| title_short | Colistin-resistance and carbapenemase-producing among carbapenem-resistance E. coli and K. pneumoniae |
| title_sort | colistin resistance and carbapenemase producing among carbapenem resistance e coli and k pneumoniae |
| topic | Klebsiella pneumoniae Escherichia coli carbapenemase colistin polymyxin E drug resistance |
| url | https://revmedmilitar.sld.cu/index.php/mil/article/view/60109 |
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