MyμAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of Care
Microalbuminemia, characterized by a urinary albumin concentration between 20 and 200 mg/L, is a critical marker in assessing the risk of chronic kidney disease (CKD), diabetic nephropathy, and various other chronic conditions. Previously, we developed and validated the MyACR point-of-care (PoC) dev...
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| Format: | Article |
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MDPI AG
2025-06-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/6/391 |
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| author | Wanna Chaijaroenkul Napaporn Youngvises Artitaya Thiengsusuk Tullayakorn Plengsuriyakarn Jakkrapong Suwanboriboon Kridsada Sirisabhabhorn Wanchai Meesiri Kesara Na-Bangchang |
| author_facet | Wanna Chaijaroenkul Napaporn Youngvises Artitaya Thiengsusuk Tullayakorn Plengsuriyakarn Jakkrapong Suwanboriboon Kridsada Sirisabhabhorn Wanchai Meesiri Kesara Na-Bangchang |
| author_sort | Wanna Chaijaroenkul |
| collection | DOAJ |
| description | Microalbuminemia, characterized by a urinary albumin concentration between 20 and 200 mg/L, is a critical marker in assessing the risk of chronic kidney disease (CKD), diabetic nephropathy, and various other chronic conditions. Previously, we developed and validated the MyACR point-of-care (PoC) device, which facilitates the monitoring of CKD progression through real-time data transmission, thus enhancing patient management. This device utilizes a spectrophotometric dye-binding assay to measure albumin and creatinine concentrations in urine samples, providing an albumin-to-creatinine ratio (ACR) result. In the present study, we introduced a refined version of the PoC device, MyμAlbumin, designed to offer a simple, accurate, specific, sensitive, and rapid method for detecting microalbumin in urine as an early indicator of CKD and related diseases. The measurement is based on a specific immunoturbidimetric assay in a microcuvette, using a total solution volume of 125 µL (n = 5 for each validation test). The MyμAlbumin device demonstrated excellent performance, achieving high accuracy (%DMV ≤ 4.67) and precision (%CV < 5) and a strong correlation (R<sup>2</sup> > 0.995) with laboratory spectrophotometry (dye-binding assay) and reference hospital-based immunoturbidimetric assay. Its high sensitivity (LOQ = 5 mg/L) positions MyμAlbumin as a highly viable and cost-effective tool for clinical use. Additionally, the device supports real-time, seamless data transmission, making it ideal for integration into remote healthcare settings. |
| format | Article |
| id | doaj-art-20ce734129de4fa5b406361e8a5136d4 |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-20ce734129de4fa5b406361e8a5136d42025-08-20T03:26:25ZengMDPI AGBiosensors2079-63742025-06-0115639110.3390/bios15060391MyμAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of CareWanna Chaijaroenkul0Napaporn Youngvises1Artitaya Thiengsusuk2Tullayakorn Plengsuriyakarn3Jakkrapong Suwanboriboon4Kridsada Sirisabhabhorn5Wanchai Meesiri6Kesara Na-Bangchang7Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, ThailandDrug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, ThailandDrug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, ThailandGraduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, ThailandBangkok High Lab Co., Ltd., Bang Khen District, Bangkok 10220, ThailandDepartment of Medical Technology Laboratory, Thammasat University Hospital, Pathum Thani 12120, ThailandBangkok High Lab Co., Ltd., Bang Khen District, Bangkok 10220, ThailandGraduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, ThailandMicroalbuminemia, characterized by a urinary albumin concentration between 20 and 200 mg/L, is a critical marker in assessing the risk of chronic kidney disease (CKD), diabetic nephropathy, and various other chronic conditions. Previously, we developed and validated the MyACR point-of-care (PoC) device, which facilitates the monitoring of CKD progression through real-time data transmission, thus enhancing patient management. This device utilizes a spectrophotometric dye-binding assay to measure albumin and creatinine concentrations in urine samples, providing an albumin-to-creatinine ratio (ACR) result. In the present study, we introduced a refined version of the PoC device, MyμAlbumin, designed to offer a simple, accurate, specific, sensitive, and rapid method for detecting microalbumin in urine as an early indicator of CKD and related diseases. The measurement is based on a specific immunoturbidimetric assay in a microcuvette, using a total solution volume of 125 µL (n = 5 for each validation test). The MyμAlbumin device demonstrated excellent performance, achieving high accuracy (%DMV ≤ 4.67) and precision (%CV < 5) and a strong correlation (R<sup>2</sup> > 0.995) with laboratory spectrophotometry (dye-binding assay) and reference hospital-based immunoturbidimetric assay. Its high sensitivity (LOQ = 5 mg/L) positions MyμAlbumin as a highly viable and cost-effective tool for clinical use. Additionally, the device supports real-time, seamless data transmission, making it ideal for integration into remote healthcare settings.https://www.mdpi.com/2079-6374/15/6/391microalbuminpoint-of-care (PoC) medical devicechronic kidney disease |
| spellingShingle | Wanna Chaijaroenkul Napaporn Youngvises Artitaya Thiengsusuk Tullayakorn Plengsuriyakarn Jakkrapong Suwanboriboon Kridsada Sirisabhabhorn Wanchai Meesiri Kesara Na-Bangchang MyμAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of Care Biosensors microalbumin point-of-care (PoC) medical device chronic kidney disease |
| title | MyμAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of Care |
| title_full | MyμAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of Care |
| title_fullStr | MyμAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of Care |
| title_full_unstemmed | MyμAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of Care |
| title_short | MyμAlbumin: A Cutting-Edge Immunoturbidity-Based Device with Real-Time and Seamless Data Transmission for Early Detection of Chronic Kidney Disease at the Point of Care |
| title_sort | myμalbumin a cutting edge immunoturbidity based device with real time and seamless data transmission for early detection of chronic kidney disease at the point of care |
| topic | microalbumin point-of-care (PoC) medical device chronic kidney disease |
| url | https://www.mdpi.com/2079-6374/15/6/391 |
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