Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol
The therapeutic potential of medicinal plants is noted because of the presence of varieties of biochemicals. The monoterpenes, like nerol, estragole, and 3,7-dimethyl-1-octanol, have been reported for antimicrobial, antifungal, anthelmintic, and antioxidant activities. This study evaluated the toxic...
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| Format: | Article |
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Wiley
2022-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2022/8002766 |
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| author | Mayara Ladeira Coêlho Muhammad Torequl Islam George Laylson da Silva Oliveira Marcus Vinicius Oliveira Barros de Alencar José Victor de Oliveira Santos Antonielly Campinho dos Reis Ana Maria Oliveira Ferreira da Mata Márcia Fernanda Correia Jardim Paz Anca Oana Docea Daniela Calina Javad Sharifi-Rad Ana Amélia de Carvalho Melo-Cavalcante |
| author_facet | Mayara Ladeira Coêlho Muhammad Torequl Islam George Laylson da Silva Oliveira Marcus Vinicius Oliveira Barros de Alencar José Victor de Oliveira Santos Antonielly Campinho dos Reis Ana Maria Oliveira Ferreira da Mata Márcia Fernanda Correia Jardim Paz Anca Oana Docea Daniela Calina Javad Sharifi-Rad Ana Amélia de Carvalho Melo-Cavalcante |
| author_sort | Mayara Ladeira Coêlho |
| collection | DOAJ |
| description | The therapeutic potential of medicinal plants is noted because of the presence of varieties of biochemicals. The monoterpenes, like nerol, estragole, and 3,7-dimethyl-1-octanol, have been reported for antimicrobial, antifungal, anthelmintic, and antioxidant activities. This study evaluated the toxic, cytotoxic, and oxidant/antioxidant effects of these compounds by several in vitro (DPPH and ABTS radical scavenging, and ferric reducing potential), ex vivo (hemolysis), and in vivo (Artemia Salina and Saccharomyces cerevisiae) assays. Results suggest that estragole and 3,7-dimethyl-1-octanol at 31.25–500 μg/mL did not exhibit significant cytotoxic effects in the A. Salina and hemolysis tests. Nerol showed significant cytotoxic effects on these test systems at all test concentrations. The monoterpenes showed radical (ABTS•+ and DPPH•) scavenging capacities in a concentration-dependent manner in vitro tests. However, they did not oxidize the genetic material of S. cerevisiae (SODWT, Sod1Δ, Sod2Δ, Sod1/Sod2Δ, Cat1Δ, and Cat1Δ/Sod1Δ) lines. Among the three monoterpenes, nerol may be a good candidate for antioxidant and anti-tumor therapies. |
| format | Article |
| id | doaj-art-20c68fcb91cc4965946e749f642c799e |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-20c68fcb91cc4965946e749f642c799e2025-08-20T03:54:47ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902022-01-01202210.1155/2022/8002766Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-OctanolMayara Ladeira Coêlho0Muhammad Torequl Islam1George Laylson da Silva Oliveira2Marcus Vinicius Oliveira Barros de Alencar3José Victor de Oliveira Santos4Antonielly Campinho dos Reis5Ana Maria Oliveira Ferreira da Mata6Márcia Fernanda Correia Jardim Paz7Anca Oana Docea8Daniela Calina9Javad Sharifi-Rad10Ana Amélia de Carvalho Melo-Cavalcante11Northeast Biotechnology Network (RENORBIO)Department of PharmacyNortheast Biotechnology Network (RENORBIO)Northeast Biotechnology Network (RENORBIO)Post-Graduation Program in Pharmaceutical ScienceIntegral Diferencial College (FACID-DEVRY)Post-Graduation Program in Pharmaceutical ScienceNortheast Biotechnology Network (RENORBIO)Department of ToxicologyDepartment of Clinical PharmacyFacultad de MedicinaNortheast Biotechnology Network (RENORBIO)The therapeutic potential of medicinal plants is noted because of the presence of varieties of biochemicals. The monoterpenes, like nerol, estragole, and 3,7-dimethyl-1-octanol, have been reported for antimicrobial, antifungal, anthelmintic, and antioxidant activities. This study evaluated the toxic, cytotoxic, and oxidant/antioxidant effects of these compounds by several in vitro (DPPH and ABTS radical scavenging, and ferric reducing potential), ex vivo (hemolysis), and in vivo (Artemia Salina and Saccharomyces cerevisiae) assays. Results suggest that estragole and 3,7-dimethyl-1-octanol at 31.25–500 μg/mL did not exhibit significant cytotoxic effects in the A. Salina and hemolysis tests. Nerol showed significant cytotoxic effects on these test systems at all test concentrations. The monoterpenes showed radical (ABTS•+ and DPPH•) scavenging capacities in a concentration-dependent manner in vitro tests. However, they did not oxidize the genetic material of S. cerevisiae (SODWT, Sod1Δ, Sod2Δ, Sod1/Sod2Δ, Cat1Δ, and Cat1Δ/Sod1Δ) lines. Among the three monoterpenes, nerol may be a good candidate for antioxidant and anti-tumor therapies.http://dx.doi.org/10.1155/2022/8002766 |
| spellingShingle | Mayara Ladeira Coêlho Muhammad Torequl Islam George Laylson da Silva Oliveira Marcus Vinicius Oliveira Barros de Alencar José Victor de Oliveira Santos Antonielly Campinho dos Reis Ana Maria Oliveira Ferreira da Mata Márcia Fernanda Correia Jardim Paz Anca Oana Docea Daniela Calina Javad Sharifi-Rad Ana Amélia de Carvalho Melo-Cavalcante Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol Advances in Pharmacological and Pharmaceutical Sciences |
| title | Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol |
| title_full | Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol |
| title_fullStr | Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol |
| title_full_unstemmed | Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol |
| title_short | Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol |
| title_sort | cytotoxic and antioxidant properties of natural bioactive monoterpenes nerol estragole and 3 7 dimethyl 1 octanol |
| url | http://dx.doi.org/10.1155/2022/8002766 |
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