Cell Therapy in Patients with Critical Limb Ischemia
Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therape...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/931420 |
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| _version_ | 1832550680093523968 |
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| author | Rita Compagna Bruno Amato Salvatore Massa Maurizio Amato Raffaele Grande Lucia Butrico Stefano de Franciscis Raffaele Serra |
| author_facet | Rita Compagna Bruno Amato Salvatore Massa Maurizio Amato Raffaele Grande Lucia Butrico Stefano de Franciscis Raffaele Serra |
| author_sort | Rita Compagna |
| collection | DOAJ |
| description | Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life. |
| format | Article |
| id | doaj-art-20c381d389ef409d92b71e1e4da06a68 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-20c381d389ef409d92b71e1e4da06a682025-02-03T06:06:09ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/931420931420Cell Therapy in Patients with Critical Limb IschemiaRita Compagna0Bruno Amato1Salvatore Massa2Maurizio Amato3Raffaele Grande4Lucia Butrico5Stefano de Franciscis6Raffaele Serra7Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyDepartment of Clinical Medicine and Surgery, University of Naples “Federico II”, 80100 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples “Federico II”, 80100 Naples, ItalyDepartment of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, ItalyInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyCritical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.http://dx.doi.org/10.1155/2015/931420 |
| spellingShingle | Rita Compagna Bruno Amato Salvatore Massa Maurizio Amato Raffaele Grande Lucia Butrico Stefano de Franciscis Raffaele Serra Cell Therapy in Patients with Critical Limb Ischemia Stem Cells International |
| title | Cell Therapy in Patients with Critical Limb Ischemia |
| title_full | Cell Therapy in Patients with Critical Limb Ischemia |
| title_fullStr | Cell Therapy in Patients with Critical Limb Ischemia |
| title_full_unstemmed | Cell Therapy in Patients with Critical Limb Ischemia |
| title_short | Cell Therapy in Patients with Critical Limb Ischemia |
| title_sort | cell therapy in patients with critical limb ischemia |
| url | http://dx.doi.org/10.1155/2015/931420 |
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