Anti-inflammatory effects of NaB and NaPc in Acinetobacter baumannii-stimulated THP-1 cells via TLR-2/NF-κB/ROS/NLRP3 pathway

Anti-inflammatory effects of NaB and NaPc in Acinetobacter baumannii-stimulated THP-1 cells via TLR-2/NF-κB/ROS/NLRP3 pathway

This study evaluated the anti-inflammation effect of the three main short-chain fatty acids (SCFAs) on Acinetobacter baumannii-induced THP-1 cells. The three main SCFAs could inhibit A. baumannii-stimulated THP-1 cell NF-κB pathway activity and the expressions of NLRP3 inflamma-some and GSDMD, and i...

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Bibliographic Details
Main Authors: Shu Chen, Yan-Yan Zhang, Hai Zhang, Long-Kun Ding, Yue Xi, Man Yan, Chang Sun, Liang Wu, Hao Hu
Format: Article
Language:English
Published: Sciendo 2022-12-01
Series:Acta Pharmaceutica
Subjects:
short-chain fatty acids (scfas)
autophagy
nlrp3
nuclear factor-κb (nf-κb)
inflammation
Online Access:https://doi.org/10.2478/acph-2022-0036
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