Amyloid-induced mineralization: From biological systems to biomimetic materials
Amyloid deposits are widely presented in ectopic calcification associated with many degenerative diseases, such as calcific aortic valve disease and Alzheimer's disease. Recently, amyloid-like secondary structures have also been observed in matrix proteins during physiological mineralization pr...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-09-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25001847 |
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| Summary: | Amyloid deposits are widely presented in ectopic calcification associated with many degenerative diseases, such as calcific aortic valve disease and Alzheimer's disease. Recently, amyloid-like secondary structures have also been observed in matrix proteins during physiological mineralization processes. With advancing observational apparatus, the mineral-templating role of amyloid has been increasingly investigated; nevertheless, it is still challenging to elucidate the explicit contribution of amyloid-like proteins in both pathological and physiological calcification. In this review, we discuss the potential roles of amyloid-forming proteins in both pathological and physiological mineralization, the nature of the interactions between the amyloid-like structure and the mineral ions, as well as the mechanisms underlying hierarchical mineralization templated by amyloid proteins. Taking inspiration from nature's book, we summarize the cutting-edge developments in amyloid-based materials for hard tissue repair. Spanning from mechanisms to applications, this review provides valuable insights for further interdisciplinary research. |
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| ISSN: | 2452-199X |