Lung microbiota: a new hope for treating acute respiratory distress syndrome?
The lung microbiota, present in healthy individuals, undergoes alterations in different diseases and is closely linked to changes in both systemic and alveolar immunity. These interactions play a crucial role in the onset and progression of numerous diseases. Acute respiratory distress syndrome (ARD...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1586949/full |
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| author | Yao Tang Bo Liu Aijia Ma Bo Wang Huaiyu Xiong Yi Zhou Jing Yang Yan Kang |
| author_facet | Yao Tang Bo Liu Aijia Ma Bo Wang Huaiyu Xiong Yi Zhou Jing Yang Yan Kang |
| author_sort | Yao Tang |
| collection | DOAJ |
| description | The lung microbiota, present in healthy individuals, undergoes alterations in different diseases and is closely linked to changes in both systemic and alveolar immunity. These interactions play a crucial role in the onset and progression of numerous diseases. Acute respiratory distress syndrome (ARDS), one of the most severe conditions encountered in intensive care units (ICU), is characterized by high incidence and mortality rates. The pathophysiology of ARDS involves complex mechanisms, including the activation and dysregulation of overlapping pathways related to injury, inflammation, and coagulation, both locally in the lungs and systemically. Notably, alterations in the microbiota may contribute to the pathogenesis of ARDS. Emerging evidence suggests that changes in the lung microbiota are associated with ARDS development, often marked by increased bacterial burden, reduced microbial diversity, and shifts in microbiota composition. In this review, we focus on the regulatory roles of the lung microbiota in ARDS and their therapeutic potential. |
| format | Article |
| id | doaj-art-20bcb31857a84d8bb8f2276c12e4aca2 |
| institution | DOAJ |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-20bcb31857a84d8bb8f2276c12e4aca22025-08-20T03:12:38ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-05-011610.3389/fmicb.2025.15869491586949Lung microbiota: a new hope for treating acute respiratory distress syndrome?Yao Tang0Bo Liu1Aijia Ma2Bo Wang3Huaiyu Xiong4Yi Zhou5Jing Yang6Yan Kang7Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaWest China Hospital, Institutes for Systems Genetics, Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, ChinaThe lung microbiota, present in healthy individuals, undergoes alterations in different diseases and is closely linked to changes in both systemic and alveolar immunity. These interactions play a crucial role in the onset and progression of numerous diseases. Acute respiratory distress syndrome (ARDS), one of the most severe conditions encountered in intensive care units (ICU), is characterized by high incidence and mortality rates. The pathophysiology of ARDS involves complex mechanisms, including the activation and dysregulation of overlapping pathways related to injury, inflammation, and coagulation, both locally in the lungs and systemically. Notably, alterations in the microbiota may contribute to the pathogenesis of ARDS. Emerging evidence suggests that changes in the lung microbiota are associated with ARDS development, often marked by increased bacterial burden, reduced microbial diversity, and shifts in microbiota composition. In this review, we focus on the regulatory roles of the lung microbiota in ARDS and their therapeutic potential.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1586949/fulllung microbiotaARDScorona virus disease 2019 (COVID-19)prognosismetabolic products |
| spellingShingle | Yao Tang Bo Liu Aijia Ma Bo Wang Huaiyu Xiong Yi Zhou Jing Yang Yan Kang Lung microbiota: a new hope for treating acute respiratory distress syndrome? Frontiers in Microbiology lung microbiota ARDS corona virus disease 2019 (COVID-19) prognosis metabolic products |
| title | Lung microbiota: a new hope for treating acute respiratory distress syndrome? |
| title_full | Lung microbiota: a new hope for treating acute respiratory distress syndrome? |
| title_fullStr | Lung microbiota: a new hope for treating acute respiratory distress syndrome? |
| title_full_unstemmed | Lung microbiota: a new hope for treating acute respiratory distress syndrome? |
| title_short | Lung microbiota: a new hope for treating acute respiratory distress syndrome? |
| title_sort | lung microbiota a new hope for treating acute respiratory distress syndrome |
| topic | lung microbiota ARDS corona virus disease 2019 (COVID-19) prognosis metabolic products |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1586949/full |
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