REVIEWING ANTI-MALARIAL USAGE AND RESISTANCE PATTERNS AND ITS EFFECTS ON WORLD HEALTH ORGANISATION PROGRAMS
The two most significant strains of human malaria parasites responsible for morbidity and mortality are Plasmodium falciparum and P. vivax. One issue, which further compounds treatment of these pathogens, is one of drug resistance. Drug resistance often emerges from key mutations selected for by...
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| Format: | Article |
| Language: | Russian |
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Federal Scientific Centre VIEV
2016-05-01
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| Series: | Российский паразитологический журнал |
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| Online Access: | https://vniigis.elpub.ru/jour/article/view/173 |
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| author | Nikolce Kocovski William Godfrey L. L. B Derek Elkington B. Sc Christopher Weir B. Sc |
| author_facet | Nikolce Kocovski William Godfrey L. L. B Derek Elkington B. Sc Christopher Weir B. Sc |
| author_sort | Nikolce Kocovski |
| collection | DOAJ |
| description | The two most significant strains of human malaria parasites responsible for morbidity and mortality are Plasmodium falciparum and P. vivax. One issue, which further compounds treatment of these pathogens, is one of drug resistance. Drug resistance often emerges from key mutations selected for by inadequate treatment regimes and has shown to be able to spread globally, further compounding the development of newer and more effective drug treatment programs, such as those from the World Health Organisation (WHO). Here we review the historical usage of anti-malarial drugs, the development of resistance in Africa and Asia, mechanisms of drug action and resistance, and the effects of resistance on WHO policy. |
| format | Article |
| id | doaj-art-20b7bf64f79a46078ea82956e7021606 |
| institution | Kabale University |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| publishDate | 2016-05-01 |
| publisher | Federal Scientific Centre VIEV |
| record_format | Article |
| series | Российский паразитологический журнал |
| spelling | doaj-art-20b7bf64f79a46078ea82956e70216062025-08-20T03:59:17ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432016-05-01036574173REVIEWING ANTI-MALARIAL USAGE AND RESISTANCE PATTERNS AND ITS EFFECTS ON WORLD HEALTH ORGANISATION PROGRAMSNikolce Kocovski0William Godfrey L. L. B1Derek Elkington B. Sc2Christopher Weir B. Sc3Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University, Austin Health, Heidelberg 3084, Victoria, AustraliaThe School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, Queensland, AustraliaSchool of Pathology and Laboratory Medicine, University of Western Australia, Crawley 6009, Western Australia, AustraliaWalter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia; University of Melbourne, Department of Medical Biology, Parkville 3010, Victoria, Australia; University of Edinburgh, School of Chemistry, Edinburgh EH9 3FJ, Scotland, United Kingdom.The two most significant strains of human malaria parasites responsible for morbidity and mortality are Plasmodium falciparum and P. vivax. One issue, which further compounds treatment of these pathogens, is one of drug resistance. Drug resistance often emerges from key mutations selected for by inadequate treatment regimes and has shown to be able to spread globally, further compounding the development of newer and more effective drug treatment programs, such as those from the World Health Organisation (WHO). Here we review the historical usage of anti-malarial drugs, the development of resistance in Africa and Asia, mechanisms of drug action and resistance, and the effects of resistance on WHO policy.https://vniigis.elpub.ru/jour/article/view/173malariadrug-resistanceplasmodiumworld health organisationdrug policy |
| spellingShingle | Nikolce Kocovski William Godfrey L. L. B Derek Elkington B. Sc Christopher Weir B. Sc REVIEWING ANTI-MALARIAL USAGE AND RESISTANCE PATTERNS AND ITS EFFECTS ON WORLD HEALTH ORGANISATION PROGRAMS Российский паразитологический журнал malaria drug-resistance plasmodium world health organisation drug policy |
| title | REVIEWING ANTI-MALARIAL USAGE AND RESISTANCE PATTERNS AND ITS EFFECTS ON WORLD HEALTH ORGANISATION PROGRAMS |
| title_full | REVIEWING ANTI-MALARIAL USAGE AND RESISTANCE PATTERNS AND ITS EFFECTS ON WORLD HEALTH ORGANISATION PROGRAMS |
| title_fullStr | REVIEWING ANTI-MALARIAL USAGE AND RESISTANCE PATTERNS AND ITS EFFECTS ON WORLD HEALTH ORGANISATION PROGRAMS |
| title_full_unstemmed | REVIEWING ANTI-MALARIAL USAGE AND RESISTANCE PATTERNS AND ITS EFFECTS ON WORLD HEALTH ORGANISATION PROGRAMS |
| title_short | REVIEWING ANTI-MALARIAL USAGE AND RESISTANCE PATTERNS AND ITS EFFECTS ON WORLD HEALTH ORGANISATION PROGRAMS |
| title_sort | reviewing anti malarial usage and resistance patterns and its effects on world health organisation programs |
| topic | malaria drug-resistance plasmodium world health organisation drug policy |
| url | https://vniigis.elpub.ru/jour/article/view/173 |
| work_keys_str_mv | AT nikolcekocovski reviewingantimalarialusageandresistancepatternsanditseffectsonworldhealthorganisationprograms AT williamgodfreyllb reviewingantimalarialusageandresistancepatternsanditseffectsonworldhealthorganisationprograms AT derekelkingtonbsc reviewingantimalarialusageandresistancepatternsanditseffectsonworldhealthorganisationprograms AT christopherweirbsc reviewingantimalarialusageandresistancepatternsanditseffectsonworldhealthorganisationprograms |