Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB–HIF-1α–CXCL1

Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB–HIF-1α–CXCL1

Abstract Background Acute pancreatitis (AP) is a sterile inflammation, and 10–20% of cases can progress to severe acute pancreatitis (SAP), which seriously threatens human life and health. Neutrophils and their extracellular traps (NETs) play an important role in the progression of AP. However, the...

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Bibliographic Details
Main Authors: Qiang Wang, Xiao Zhang, Chenglong Han, Zhenyi Lv, Yi Zheng, Xuxu Liu, Zhiwei Du, Tianming Liu, Dongbo Xue, Tao Li, Liyi Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cellular & Molecular Biology Letters
Subjects:
Acute pancreatitis
Neutrophils
NETs
Fibroblasts
Online Access:https://doi.org/10.1186/s11658-025-00734-6
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