Saroglitazar Ameliorates Pulmonary Fibrosis Progression in Mice by Suppressing NF-κB Activation and Attenuating Macrophage M1 Polarization

Saroglitazar Ameliorates Pulmonary Fibrosis Progression in Mice by Suppressing NF-κB Activation and Attenuating Macrophage M1 Polarization

<i>Background and Objectives</i>: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with limited therapeutic options. Current therapies (pirfenidone, nintedanib) exhibit modest efficacy and significant side effects, underscoring the need for novel s...

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Bibliographic Details
Main Authors: Yawen Zhang, Jiaquan Lin, Xiaodong Han, Xiang Chen
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Medicina
Subjects:
pulmonary fibrosis
inflammation
saroglitazar
M1 macrophage polarization
NF-κB pathway
Online Access:https://www.mdpi.com/1648-9144/61/7/1157
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