Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported case
Subhepatic appendicitis complicated by hepatic abscess is an uncommon clinical condition due to anatomical variations in the appendix’s position. Here, we report an unusual case of a 56-year-old male who initially presented with right abdominal pain and fever, misdiagnosed as bilateral kidney stones...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1591905/full |
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| author | Hao Chen Miao Yu Zhanping Chang Yang Li Lei Fan Dake Shang Huili Zhang |
| author_facet | Hao Chen Miao Yu Zhanping Chang Yang Li Lei Fan Dake Shang Huili Zhang |
| author_sort | Hao Chen |
| collection | DOAJ |
| description | Subhepatic appendicitis complicated by hepatic abscess is an uncommon clinical condition due to anatomical variations in the appendix’s position. Here, we report an unusual case of a 56-year-old male who initially presented with right abdominal pain and fever, misdiagnosed as bilateral kidney stones and urinary tract infection. Subsequent abdominal CT(Computed Tomography) scans revealed subhepatic appendicitis with a hepatic abscess located in segment VI of the liver. The patient underwent successful laparoscopic appendectomy and hepatic abscess drainage. Unexpectedly, histopathological examination of the appendix demonstrated diffuse large B-cell lymphoma (DLBCL), a rare form of primary appendiceal non-Hodgkin lymphoma. Immunohistochemistry confirmed the diagnosis, with tumor cells positive for CD20, CD79a, Bcl-6, and c-Myc, and a high Ki-67 proliferative index (>90%). This case highlights the diagnostic challenges associated with atypically positioned appendicitis and underscores the importance of pathological evaluation in detecting rare underlying malignancies. |
| format | Article |
| id | doaj-art-20ab8a05252149ccb9ca073da5b4efca |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-20ab8a05252149ccb9ca073da5b4efca2025-08-20T03:45:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15919051591905Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported caseHao Chen0Miao Yu1Zhanping Chang2Yang Li3Lei Fan4Dake Shang5Huili Zhang6General Surgery, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, ChinaPathology Department, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, ChinaPathology Department, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, ChinaGeneral Surgery, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, ChinaGeneral Surgery, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, ChinaGeneral Surgery, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, ChinaGeneral Surgery, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, ChinaSubhepatic appendicitis complicated by hepatic abscess is an uncommon clinical condition due to anatomical variations in the appendix’s position. Here, we report an unusual case of a 56-year-old male who initially presented with right abdominal pain and fever, misdiagnosed as bilateral kidney stones and urinary tract infection. Subsequent abdominal CT(Computed Tomography) scans revealed subhepatic appendicitis with a hepatic abscess located in segment VI of the liver. The patient underwent successful laparoscopic appendectomy and hepatic abscess drainage. Unexpectedly, histopathological examination of the appendix demonstrated diffuse large B-cell lymphoma (DLBCL), a rare form of primary appendiceal non-Hodgkin lymphoma. Immunohistochemistry confirmed the diagnosis, with tumor cells positive for CD20, CD79a, Bcl-6, and c-Myc, and a high Ki-67 proliferative index (>90%). This case highlights the diagnostic challenges associated with atypically positioned appendicitis and underscores the importance of pathological evaluation in detecting rare underlying malignancies.https://www.frontiersin.org/articles/10.3389/fonc.2025.1591905/fullsubhepatic appendicitisliver abscessdiffuse large B-cell lymphomanon-Hodgkin lymphomaappendectomycase report |
| spellingShingle | Hao Chen Miao Yu Zhanping Chang Yang Li Lei Fan Dake Shang Huili Zhang Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported case Frontiers in Oncology subhepatic appendicitis liver abscess diffuse large B-cell lymphoma non-Hodgkin lymphoma appendectomy case report |
| title | Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported case |
| title_full | Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported case |
| title_fullStr | Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported case |
| title_full_unstemmed | Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported case |
| title_short | Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported case |
| title_sort | case report subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large b cell lymphoma of the appendix first reported case |
| topic | subhepatic appendicitis liver abscess diffuse large B-cell lymphoma non-Hodgkin lymphoma appendectomy case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1591905/full |
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