Clinical characteristics and risk factors for tuberculosis during the COVID-19 pandemic: a longitudinal analysis in a trans-border Ukrainian region
OBJECTIVE. To assess the dynamics of the clinical peculiarities and risk factors for tuberculosis (TB) during the coronavirus disease (COVID-19) pandemic through a longitudinal analysis in a trans-border Ukrainian region. MATERIALS AND METHODS. Objectives were: 1) assessment of the general peculi...
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| Format: | Article |
| Language: | English |
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Civic Union "Communicable Diseases Intensive Care Association"
2024-12-01
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| Series: | Infusion & Chemotherapy |
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| Online Access: | https://infusion-chemotherapy.com/index.php/journal/article/view/429 |
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| author | E. Lesnic L.D. Todoriko |
| author_facet | E. Lesnic L.D. Todoriko |
| author_sort | E. Lesnic |
| collection | DOAJ |
| description | OBJECTIVE. To assess the dynamics of the clinical peculiarities and risk factors for tuberculosis (TB) during the coronavirus disease (COVID-19) pandemic through a longitudinal analysis in a trans-border Ukrainian region.
MATERIALS AND METHODS. Objectives were: 1) assessment of the general peculiarities, social and epidemiological risk factors of patients diagnosed with TB clinically managed during three phases of the COVID-19 pandemic in Ukrainian trans-border region Chernivtsi; 2) evaluation of the progression in the use TB diagnostic tools and their impact on the treatment effectiveness; 3) establishing the main issues and challenges in management of TB patients during three periods of the COVID-19 pandemic in the trans-border region. A prospective, case-control study, which was conducted from 2018 to 2023, included 896 patients registered during the pre-COVID pandemic, 579 patients during initial COVID-19 pandemic and 773 patients during the late-pandemic periods.
RESULTS. While the demographic characteristics of the patients did not differ during the pre-, initial and late-pandemic periods in a trans-border Ukrainian region, their clinical aspects, case-detection, management and treatment outcome were contrasting. The dynamics was negative during the initial COVID-19 pandemic in terms of severity of the clinical, radiological and laboratory aspects, which resulted in a higher rate of patients with negative outcomes.
CONCLUSIONS. Establishing the risk factors and issues with the greatest impact of the clinical case-management is crucial for targeted prevention and early intervention strategies for maintain the TB control at the regional trans-border level. |
| format | Article |
| id | doaj-art-20a9d97f37d7472c843deb1a07dfbaa9 |
| institution | OA Journals |
| issn | 2663-0338 2709-0957 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Civic Union "Communicable Diseases Intensive Care Association" |
| record_format | Article |
| series | Infusion & Chemotherapy |
| spelling | doaj-art-20a9d97f37d7472c843deb1a07dfbaa92025-08-20T01:58:42ZengCivic Union "Communicable Diseases Intensive Care Association"Infusion & Chemotherapy2663-03382709-09572024-12-01451010.32902/2663-0338-2024-4-5-10429Clinical characteristics and risk factors for tuberculosis during the COVID-19 pandemic: a longitudinal analysis in a trans-border Ukrainian regionE. Lesnic0L.D. Todoriko1Nicolae Testemițanu State University of Medicine and Pharmacy of the Republic of Moldova, Chișinău, Republic of MoldovaBukovinian State Medical University, Chernivtsi, UkraineOBJECTIVE. To assess the dynamics of the clinical peculiarities and risk factors for tuberculosis (TB) during the coronavirus disease (COVID-19) pandemic through a longitudinal analysis in a trans-border Ukrainian region. MATERIALS AND METHODS. Objectives were: 1) assessment of the general peculiarities, social and epidemiological risk factors of patients diagnosed with TB clinically managed during three phases of the COVID-19 pandemic in Ukrainian trans-border region Chernivtsi; 2) evaluation of the progression in the use TB diagnostic tools and their impact on the treatment effectiveness; 3) establishing the main issues and challenges in management of TB patients during three periods of the COVID-19 pandemic in the trans-border region. A prospective, case-control study, which was conducted from 2018 to 2023, included 896 patients registered during the pre-COVID pandemic, 579 patients during initial COVID-19 pandemic and 773 patients during the late-pandemic periods. RESULTS. While the demographic characteristics of the patients did not differ during the pre-, initial and late-pandemic periods in a trans-border Ukrainian region, their clinical aspects, case-detection, management and treatment outcome were contrasting. The dynamics was negative during the initial COVID-19 pandemic in terms of severity of the clinical, radiological and laboratory aspects, which resulted in a higher rate of patients with negative outcomes. CONCLUSIONS. Establishing the risk factors and issues with the greatest impact of the clinical case-management is crucial for targeted prevention and early intervention strategies for maintain the TB control at the regional trans-border level.https://infusion-chemotherapy.com/index.php/journal/article/view/429tuberculosisrisk factorstreatmentoutcome |
| spellingShingle | E. Lesnic L.D. Todoriko Clinical characteristics and risk factors for tuberculosis during the COVID-19 pandemic: a longitudinal analysis in a trans-border Ukrainian region Infusion & Chemotherapy tuberculosis risk factors treatment outcome |
| title | Clinical characteristics and risk factors for tuberculosis during the COVID-19 pandemic: a longitudinal analysis in a trans-border Ukrainian region |
| title_full | Clinical characteristics and risk factors for tuberculosis during the COVID-19 pandemic: a longitudinal analysis in a trans-border Ukrainian region |
| title_fullStr | Clinical characteristics and risk factors for tuberculosis during the COVID-19 pandemic: a longitudinal analysis in a trans-border Ukrainian region |
| title_full_unstemmed | Clinical characteristics and risk factors for tuberculosis during the COVID-19 pandemic: a longitudinal analysis in a trans-border Ukrainian region |
| title_short | Clinical characteristics and risk factors for tuberculosis during the COVID-19 pandemic: a longitudinal analysis in a trans-border Ukrainian region |
| title_sort | clinical characteristics and risk factors for tuberculosis during the covid 19 pandemic a longitudinal analysis in a trans border ukrainian region |
| topic | tuberculosis risk factors treatment outcome |
| url | https://infusion-chemotherapy.com/index.php/journal/article/view/429 |
| work_keys_str_mv | AT elesnic clinicalcharacteristicsandriskfactorsfortuberculosisduringthecovid19pandemicalongitudinalanalysisinatransborderukrainianregion AT ldtodoriko clinicalcharacteristicsandriskfactorsfortuberculosisduringthecovid19pandemicalongitudinalanalysisinatransborderukrainianregion |