Clinical characteristics and risk factors for tuberculosis during the COVID-19 pandemic: a longitudinal analysis in a trans-border Ukrainian region
OBJECTIVE. To assess the dynamics of the clinical peculiarities and risk factors for tuberculosis (TB) during the coronavirus disease (COVID-19) pandemic through a longitudinal analysis in a trans-border Ukrainian region. MATERIALS AND METHODS. Objectives were: 1) assessment of the general peculi...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Civic Union "Communicable Diseases Intensive Care Association"
2024-12-01
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| Series: | Infusion & Chemotherapy |
| Subjects: | |
| Online Access: | https://infusion-chemotherapy.com/index.php/journal/article/view/429 |
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| Summary: | OBJECTIVE. To assess the dynamics of the clinical peculiarities and risk factors for tuberculosis (TB) during the coronavirus disease (COVID-19) pandemic through a longitudinal analysis in a trans-border Ukrainian region.
MATERIALS AND METHODS. Objectives were: 1) assessment of the general peculiarities, social and epidemiological risk factors of patients diagnosed with TB clinically managed during three phases of the COVID-19 pandemic in Ukrainian trans-border region Chernivtsi; 2) evaluation of the progression in the use TB diagnostic tools and their impact on the treatment effectiveness; 3) establishing the main issues and challenges in management of TB patients during three periods of the COVID-19 pandemic in the trans-border region. A prospective, case-control study, which was conducted from 2018 to 2023, included 896 patients registered during the pre-COVID pandemic, 579 patients during initial COVID-19 pandemic and 773 patients during the late-pandemic periods.
RESULTS. While the demographic characteristics of the patients did not differ during the pre-, initial and late-pandemic periods in a trans-border Ukrainian region, their clinical aspects, case-detection, management and treatment outcome were contrasting. The dynamics was negative during the initial COVID-19 pandemic in terms of severity of the clinical, radiological and laboratory aspects, which resulted in a higher rate of patients with negative outcomes.
CONCLUSIONS. Establishing the risk factors and issues with the greatest impact of the clinical case-management is crucial for targeted prevention and early intervention strategies for maintain the TB control at the regional trans-border level. |
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| ISSN: | 2663-0338 2709-0957 |