Dynamic Transcriptomic and Cellular Remodeling Underlie Cuprizone-Induced Demyelination and Endogenous Repair in the CNS

Dynamic Transcriptomic and Cellular Remodeling Underlie Cuprizone-Induced Demyelination and Endogenous Repair in the CNS

Demyelination in the central nervous system (CNS) disrupts neuronal communication and promotes neurodegeneration. Despite the widespread use of cuprizone-induced demyelination models to study myelin injury and repair, the mechanisms underlying oligodendrocyte apoptosis and regeneration are poorly un...

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Bibliographic Details
Main Authors: Yantuanjin Ma, Tianyi Liu, Zhipeng Li, Wei Wei, Qiting Zhao, Shufen Wang
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antioxidants
Subjects:
cuprizone
demyelination
remyelination
blood–brain barrier integrity
glial cell
neuroinflammation
Online Access:https://www.mdpi.com/2076-3921/14/6/692
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