Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, India
Background: During pregnancy, the physiological production of reactive oxygen species (ROS) is associated with a variety of maternal, placental, and fetal developmental functions. These functions are disrupted by excessive amounts of ROS, resulting to pregnancy complications. Different stages of pr...
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| Language: | English |
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Indonesian Society for Biochemistry and Molecular Biology
2022-12-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/89 |
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| author | Niharika Singh Saba Khan Mohammad Mustufa Khan Haseeb Ahsan Roshan Alam |
| author_facet | Niharika Singh Saba Khan Mohammad Mustufa Khan Haseeb Ahsan Roshan Alam |
| author_sort | Niharika Singh |
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Background: During pregnancy, the physiological production of reactive oxygen species (ROS) is associated with a variety of maternal, placental, and fetal developmental functions. These functions are disrupted by excessive amounts of ROS, resulting to pregnancy complications. Different stages of pregnancy require a balance between oxidant and antioxidant production.
Objective: The aim of this study is to investigate the status of malondialdehyde (MDA) and catalase (CAT) activity in pregnant and age matched non-pregnant women.
Methods: In this cross-sectional study, a total of 74 participants were enrolled, including 37 pregnant and 37 age-matched non-pregnant women. The age range of participants was 18 to 40 years. MDA and CAT levels were measured spectrophotometrically. A p-value 0.05 was statistically significant.
Results: Compared to non-pregnant women, the mean plasma level of MDA was considerably elevated in pregnant women (p<0.0001). However, the mean level of CAT activity in pregnant women was significantly lower than in non-pregnant women (p<0.0001) In pregnant women, there is a significant strong negative correlation between MDA levels and CAT activity (p<0.01).
Conclusion: Pregnant women have high level of oxidative stress, indicating that the pregnant women are more susceptible to oxidative damage and may develop pregnancy-associated complications.
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| format | Article |
| id | doaj-art-20a6dd6c1d934b2bbfa731ff263bf7de |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-20a6dd6c1d934b2bbfa731ff263bf7de2025-02-08T03:05:57ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222022-12-015210.32889/actabioina.89Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, IndiaNiharika Singh0Saba Khan1Mohammad Mustufa Khan2Haseeb Ahsan3Roshan Alam4Department of Biochemistry, Integral Institute of Medical Sciences & Research (IIMS&R), Integral University, Lucknow, UP, India.Department of Biochemistry, Integral Institute of Medical Sciences & Research (IIMS&R), Integral University, Lucknow, UP, India.Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences & Research (IIAHS&R), Integral University, Lucknow, UP, IndiaDepartment of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, IndiaDepartment of Biochemistry, Integral Institute of Medical Sciences & Research (IIMS&R), Integral University, Lucknow, UP, India. Background: During pregnancy, the physiological production of reactive oxygen species (ROS) is associated with a variety of maternal, placental, and fetal developmental functions. These functions are disrupted by excessive amounts of ROS, resulting to pregnancy complications. Different stages of pregnancy require a balance between oxidant and antioxidant production. Objective: The aim of this study is to investigate the status of malondialdehyde (MDA) and catalase (CAT) activity in pregnant and age matched non-pregnant women. Methods: In this cross-sectional study, a total of 74 participants were enrolled, including 37 pregnant and 37 age-matched non-pregnant women. The age range of participants was 18 to 40 years. MDA and CAT levels were measured spectrophotometrically. A p-value 0.05 was statistically significant. Results: Compared to non-pregnant women, the mean plasma level of MDA was considerably elevated in pregnant women (p<0.0001). However, the mean level of CAT activity in pregnant women was significantly lower than in non-pregnant women (p<0.0001) In pregnant women, there is a significant strong negative correlation between MDA levels and CAT activity (p<0.01). Conclusion: Pregnant women have high level of oxidative stress, indicating that the pregnant women are more susceptible to oxidative damage and may develop pregnancy-associated complications. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/89catalaseoxidative stressmalondialdehydepregnancyreactive oxygen species |
| spellingShingle | Niharika Singh Saba Khan Mohammad Mustufa Khan Haseeb Ahsan Roshan Alam Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, India Acta Biochimica Indonesiana catalase oxidative stress malondialdehyde pregnancy reactive oxygen species |
| title | Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, India |
| title_full | Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, India |
| title_fullStr | Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, India |
| title_full_unstemmed | Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, India |
| title_short | Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, India |
| title_sort | estimation of malondialdehyde and catalase activity in pregnant women at iims r hospital lucknow india |
| topic | catalase oxidative stress malondialdehyde pregnancy reactive oxygen species |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/89 |
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