Assessing Adventitious Matches of Non-Donors Related to True Contributors
Relatives share more DNA with one another than unrelated individuals. Therefore, there is an increased risk of close relatives (e.g., siblings or parents and children of true donors) adventitiously ‘matching’ DNA mixtures to which they are not a true contributor. One such method of addressing relati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/3/398 |
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| author | Kaitlin Huffman Lilliana Moreno |
| author_facet | Kaitlin Huffman Lilliana Moreno |
| author_sort | Kaitlin Huffman |
| collection | DOAJ |
| description | Relatives share more DNA with one another than unrelated individuals. Therefore, there is an increased risk of close relatives (e.g., siblings or parents and children of true donors) adventitiously ‘matching’ DNA mixtures to which they are not a true contributor. One such method of addressing relatives is to utilize alternative propositions within probabilistic genotyping software (e.g., STRmix<sup>TM</sup>). As the number of related individuals within a mixture increases, so does the potential for adventitious matches of related non-donors to the mixture due to increased allele sharing. The extent to which siblings and parents/children of true donors result in adventitious matches to mixtures in which they are non-donors is presented as well as the impact of overestimating the number of contributors (NOC) when related donors are in question. |
| format | Article |
| id | doaj-art-20a3e4b577bf4f059225bb0727d6e948 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-20a3e4b577bf4f059225bb0727d6e9482025-08-20T03:43:02ZengMDPI AGBiomolecules2218-273X2025-03-0115339810.3390/biom15030398Assessing Adventitious Matches of Non-Donors Related to True ContributorsKaitlin Huffman0Lilliana Moreno1DNA Support Unit, Federal Bureau of Investigation Laboratory, Quantico, VA 22135, USADNA Support Unit, Federal Bureau of Investigation Laboratory, Quantico, VA 22135, USARelatives share more DNA with one another than unrelated individuals. Therefore, there is an increased risk of close relatives (e.g., siblings or parents and children of true donors) adventitiously ‘matching’ DNA mixtures to which they are not a true contributor. One such method of addressing relatives is to utilize alternative propositions within probabilistic genotyping software (e.g., STRmix<sup>TM</sup>). As the number of related individuals within a mixture increases, so does the potential for adventitious matches of related non-donors to the mixture due to increased allele sharing. The extent to which siblings and parents/children of true donors result in adventitious matches to mixtures in which they are non-donors is presented as well as the impact of overestimating the number of contributors (NOC) when related donors are in question.https://www.mdpi.com/2218-273X/15/3/398probabilistic genotypingcomplex mixturesrelated non-donors |
| spellingShingle | Kaitlin Huffman Lilliana Moreno Assessing Adventitious Matches of Non-Donors Related to True Contributors Biomolecules probabilistic genotyping complex mixtures related non-donors |
| title | Assessing Adventitious Matches of Non-Donors Related to True Contributors |
| title_full | Assessing Adventitious Matches of Non-Donors Related to True Contributors |
| title_fullStr | Assessing Adventitious Matches of Non-Donors Related to True Contributors |
| title_full_unstemmed | Assessing Adventitious Matches of Non-Donors Related to True Contributors |
| title_short | Assessing Adventitious Matches of Non-Donors Related to True Contributors |
| title_sort | assessing adventitious matches of non donors related to true contributors |
| topic | probabilistic genotyping complex mixtures related non-donors |
| url | https://www.mdpi.com/2218-273X/15/3/398 |
| work_keys_str_mv | AT kaitlinhuffman assessingadventitiousmatchesofnondonorsrelatedtotruecontributors AT lillianamoreno assessingadventitiousmatchesofnondonorsrelatedtotruecontributors |