Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK
AIM: To compare the efficacy of 3% diquafosol sodium (DQS) eye drops at different frequencies in dry eye (DE) after femtosecond laser-assisted in situ keratomileusis (FS-LASIK). METHODS: In this prospective study, DE patients after FS-LASIK were randomly divided into two groups. All patients were ad...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-06-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/6/20250604.pdf |
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| author | Jin-Jin Wang Ao-Miao Yu Chang Liu Yue Huang Rui-Bo Yang Chen Zhang Hui Liu Shao-Zhen Zhao |
| author_facet | Jin-Jin Wang Ao-Miao Yu Chang Liu Yue Huang Rui-Bo Yang Chen Zhang Hui Liu Shao-Zhen Zhao |
| author_sort | Jin-Jin Wang |
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| description | AIM: To compare the efficacy of 3% diquafosol sodium (DQS) eye drops at different frequencies in dry eye (DE) after femtosecond laser-assisted in situ keratomileusis (FS-LASIK). METHODS: In this prospective study, DE patients after FS-LASIK were randomly divided into two groups. All patients were administered routine anti-inflammatory and anti-infective drugs after FS-LASIK. Additionally, both groups were treated with DQS, at frequencies of 4 (DQS4 group) and 6 (DQS6 group) times daily. Corneal fluorescein staining (CFS) score, non-invasive tear breakup time (NIBUT), tear meniscus height (TMH), lipid layer thickness (LLT), and incomplete blink rate (IBR) were assessed in patients preoperatively and at 1wk, 1, and 3mo postoperatively. The Ocular Surface Disease Index (OSDI) questionnaire was also administered. RESULTS: Totally 119 patients (238 eyes) were randomly divided into the DQS4 group (60 individuals with 120 eyes) and DQS6 group (59 individuals with 118 eyes). From 1wk to 1mo after FS-LASIK, the CFS score in the DQS6 group decreased with statistical significance (P=0.014), while the DQS4 group showed an upward trend. Comparing with preoperative values, the NIBUT of both groups was significantly prolonged at various time points after FS-LASIK (P<0.05). Within 1mo post FS-LASIK, both groups had significantly higher OSDI scores compared with preoperative values (P<0.05). At postoperative 3mo, the DQS4 group recovered to a level similar to that before surgery (P>0.05), while the DQS6 group remained a little higher than preoperative values (P>0.05). The TMH levels in the DQS4 group increased significantly at 1wk postoperatively (P<0.05), while there was no statistically significant change in the TMH levels in the DQS6 group (P>0.05). There was no significant difference in IBR and LLT between the two groups within 1mo postoperatively. At postoperative 3mo, the LLT in the DQS4 group was significantly higher than that in the DQS6 group (P<0.05). CONCLUSION: Within 1mo post-FS-LASIK, applying DQS six times daily is superior to four daily applications in improving CFS score, and in increasing NIBUT meanwhile. After 1mo, applying DQS four times daily also effectively alleviate DE symptoms and improve DE signs. Therefore, we recommend DE patients using DQS eye drops 6 times daily within 1mo after FS-LASIK, and maintaining it 4 times daily until 3mo postoperatively. |
| format | Article |
| id | doaj-art-20a18c3a7d89428dadd3fade35a15b56 |
| institution | OA Journals |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
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| series | International Journal of Ophthalmology |
| spelling | doaj-art-20a18c3a7d89428dadd3fade35a15b562025-08-20T01:55:34ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-06-01186996100210.18240/ijo.2025.06.0420250604Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIKJin-Jin Wang0Ao-Miao Yu1Chang Liu2Yue Huang3Rui-Bo Yang4Chen Zhang5Hui Liu6Shao-Zhen Zhao7Shao-Zhen Zhao. Tianjin Medical University Eye Hospital, No.251, Fukang Road, Nankai District, Tianjin 300384, China. zhaosz1997@sina.comTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China;Co-first Authors: Jin-Jin Wang and Ao-Miao YuTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China;Co-first Authors: Jin-Jin Wang and Ao-Miao YuTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China;Co-first Authors: Jin-Jin Wang and Ao-Miao YuTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China;Co-first Authors: Jin-Jin Wang and Ao-Miao YuTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China;Co-first Authors: Jin-Jin Wang and Ao-Miao YuTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China;Co-first Authors: Jin-Jin Wang and Ao-Miao YuTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China;Co-first Authors: Jin-Jin Wang and Ao-Miao YuAIM: To compare the efficacy of 3% diquafosol sodium (DQS) eye drops at different frequencies in dry eye (DE) after femtosecond laser-assisted in situ keratomileusis (FS-LASIK). METHODS: In this prospective study, DE patients after FS-LASIK were randomly divided into two groups. All patients were administered routine anti-inflammatory and anti-infective drugs after FS-LASIK. Additionally, both groups were treated with DQS, at frequencies of 4 (DQS4 group) and 6 (DQS6 group) times daily. Corneal fluorescein staining (CFS) score, non-invasive tear breakup time (NIBUT), tear meniscus height (TMH), lipid layer thickness (LLT), and incomplete blink rate (IBR) were assessed in patients preoperatively and at 1wk, 1, and 3mo postoperatively. The Ocular Surface Disease Index (OSDI) questionnaire was also administered. RESULTS: Totally 119 patients (238 eyes) were randomly divided into the DQS4 group (60 individuals with 120 eyes) and DQS6 group (59 individuals with 118 eyes). From 1wk to 1mo after FS-LASIK, the CFS score in the DQS6 group decreased with statistical significance (P=0.014), while the DQS4 group showed an upward trend. Comparing with preoperative values, the NIBUT of both groups was significantly prolonged at various time points after FS-LASIK (P<0.05). Within 1mo post FS-LASIK, both groups had significantly higher OSDI scores compared with preoperative values (P<0.05). At postoperative 3mo, the DQS4 group recovered to a level similar to that before surgery (P>0.05), while the DQS6 group remained a little higher than preoperative values (P>0.05). The TMH levels in the DQS4 group increased significantly at 1wk postoperatively (P<0.05), while there was no statistically significant change in the TMH levels in the DQS6 group (P>0.05). There was no significant difference in IBR and LLT between the two groups within 1mo postoperatively. At postoperative 3mo, the LLT in the DQS4 group was significantly higher than that in the DQS6 group (P<0.05). CONCLUSION: Within 1mo post-FS-LASIK, applying DQS six times daily is superior to four daily applications in improving CFS score, and in increasing NIBUT meanwhile. After 1mo, applying DQS four times daily also effectively alleviate DE symptoms and improve DE signs. Therefore, we recommend DE patients using DQS eye drops 6 times daily within 1mo after FS-LASIK, and maintaining it 4 times daily until 3mo postoperatively.http://ies.ijo.cn/en_publish/2025/6/20250604.pdfdiquafosolfrequenciesdry eyefemtosecond laser-assisted in situ keratomileusis |
| spellingShingle | Jin-Jin Wang Ao-Miao Yu Chang Liu Yue Huang Rui-Bo Yang Chen Zhang Hui Liu Shao-Zhen Zhao Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK International Journal of Ophthalmology diquafosol frequencies dry eye femtosecond laser-assisted in situ keratomileusis |
| title | Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK |
| title_full | Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK |
| title_fullStr | Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK |
| title_full_unstemmed | Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK |
| title_short | Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK |
| title_sort | efficacy of 3 diquafosol sodium eye drops at different frequencies in the treatment of dry eye after fs lasik |
| topic | diquafosol frequencies dry eye femtosecond laser-assisted in situ keratomileusis |
| url | http://ies.ijo.cn/en_publish/2025/6/20250604.pdf |
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