Cell size distributions in lineages
Cells actively regulate their size during the cell cycle to maintain volume homeostasis across generations. While various mathematical models of cell size regulation have been proposed to explain how this is achieved, relating these models to experimentally observed cell size distributions has prove...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American Physical Society
2025-03-01
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| Series: | Physical Review Research |
| Online Access: | http://doi.org/10.1103/PhysRevResearch.7.013302 |
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| _version_ | 1849338957993607168 |
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| author | Kaan Öcal Michael P. H. Stumpf |
| author_facet | Kaan Öcal Michael P. H. Stumpf |
| author_sort | Kaan Öcal |
| collection | DOAJ |
| description | Cells actively regulate their size during the cell cycle to maintain volume homeostasis across generations. While various mathematical models of cell size regulation have been proposed to explain how this is achieved, relating these models to experimentally observed cell size distributions has proved challenging. In this paper we present a simple formula for the cell size distribution in lineages as observed in, e.g., a mother machine, and provide a new derivation for the corresponding result in populations, assuming exponential cell growth. Our results are independent of the underlying cell size control mechanism and explain the characteristic shape underlying experimentally observed cell size distributions. We furthermore derive universal moment identities for these distributions and show that our predictions agree well with experimental measurements of E. coli cells, both on the distribution and the moment level. |
| format | Article |
| id | doaj-art-209c295326a1437da9cf2c6786e5c4d2 |
| institution | Kabale University |
| issn | 2643-1564 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review Research |
| spelling | doaj-art-209c295326a1437da9cf2c6786e5c4d22025-08-20T03:44:14ZengAmerican Physical SocietyPhysical Review Research2643-15642025-03-017101330210.1103/PhysRevResearch.7.013302Cell size distributions in lineagesKaan ÖcalMichael P. H. StumpfCells actively regulate their size during the cell cycle to maintain volume homeostasis across generations. While various mathematical models of cell size regulation have been proposed to explain how this is achieved, relating these models to experimentally observed cell size distributions has proved challenging. In this paper we present a simple formula for the cell size distribution in lineages as observed in, e.g., a mother machine, and provide a new derivation for the corresponding result in populations, assuming exponential cell growth. Our results are independent of the underlying cell size control mechanism and explain the characteristic shape underlying experimentally observed cell size distributions. We furthermore derive universal moment identities for these distributions and show that our predictions agree well with experimental measurements of E. coli cells, both on the distribution and the moment level.http://doi.org/10.1103/PhysRevResearch.7.013302 |
| spellingShingle | Kaan Öcal Michael P. H. Stumpf Cell size distributions in lineages Physical Review Research |
| title | Cell size distributions in lineages |
| title_full | Cell size distributions in lineages |
| title_fullStr | Cell size distributions in lineages |
| title_full_unstemmed | Cell size distributions in lineages |
| title_short | Cell size distributions in lineages |
| title_sort | cell size distributions in lineages |
| url | http://doi.org/10.1103/PhysRevResearch.7.013302 |
| work_keys_str_mv | AT kaanocal cellsizedistributionsinlineages AT michaelphstumpf cellsizedistributionsinlineages |