hnRNPA2B1 facilitates ovarian carcinoma metastasis by sorting cargoes into small extracellular vesicles driving myofibroblasts activation

hnRNPA2B1 facilitates ovarian carcinoma metastasis by sorting cargoes into small extracellular vesicles driving myofibroblasts activation

Abstract Background Ovarian carcinoma (OvCa) metastasis is initiated and boosted by tumor-stroma interactions mediated by small extracellular vesicles (sEVs) containing microRNAs (miRNAs). However, the mechanisms of sorting relevant miRNAs into tumoral sEVs remain elusive. Results In this study, amo...

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Main Authors: Qiulei Wu, Pan Liu, Xiaoli Liu, Guoqing Li, Lin Huang, Feiquan Ying, Lanqing Gong, Wenhan Li, Jingni Zhang, Rui Gao, Xiaoqing Yi, Linjuan Xu, Lili Yu, Zehua Wang, Jing Cai
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Ovarian cancer
Cancer-associated fibroblasts
RNA binding protein
Exosome
Noncoding RNA
Online Access:https://doi.org/10.1186/s12951-025-03342-w
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