Next-generation sequencing of CCR5, CXCR4, and IFNAR1 variants in relation to HIV-1 disease progression and ART response

Next-generation sequencing of CCR5, CXCR4, and IFNAR1 variants in relation to HIV-1 disease progression and ART response

Abstract HIV, which causes acquired immune deficiency syndrome (AIDS), invades the host cell via the CD4 receptor and CCR5 or CXCR4 co-receptors. Interferons induced early in HIV infection induce an antiviral defense mechanism through IFNAR signaling. Our study aimed to examine the relationship betw...

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Bibliographic Details
Main Authors: Kubra Cigdem Pekkoc-Uyanik, Zeynep Gizem Todurga-Seven, Andleeb Shahzadi, Haktan Sonmez, Sevcan Mercan, Bilgul Mete, Fehmi Tabak
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Next-generation sequencing
HIV
CCR5
CXCR4
IFNAR1
Polymophism
Online Access:https://doi.org/10.1038/s41598-025-11843-9
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