Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults
Background. Different taste preferences correlated with genetic variations may lead to food consumption patterns that contribute to nutrient-related health outcomes such as hypertension. Objectives. The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) in the salt tas...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2021/5559831 |
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| author | Pradtana Tapanee Diane K. Tidwell M. Wes Schilling Daniel G. Peterson Terezie Tolar-Peterson |
| author_facet | Pradtana Tapanee Diane K. Tidwell M. Wes Schilling Daniel G. Peterson Terezie Tolar-Peterson |
| author_sort | Pradtana Tapanee |
| collection | DOAJ |
| description | Background. Different taste preferences correlated with genetic variations may lead to food consumption patterns that contribute to nutrient-related health outcomes such as hypertension. Objectives. The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) in the salt taste receptor genes SCNN1B and TRPV1 affect salt taste perception among normotensive and hypertensive people. Materials and Methods. We conducted a cross-sectional case control study by design consisting of a normotensive and hypertensive group. Participants were 253 adults with age range of 20–82 residing in Mississippi, USA. For each of 128 normotensives and 125 hypertensives, the salt taste recognition threshold and salt taste receptor genotype were determined. Results. The hypertensive group had a higher salt taste recognition threshold than the normotensive group (P<0.001). The polymorphism of TRPV1, rs4790522, with the AA genotype was associated with a higher salt recognition threshold (lower salt taste sensitivity) in people with hypertension and obesity. Moreover, the polymorphism of TRPV1, rs8065080, and SCNN1B, rs239345, genes were associated with a risk of hypertension (P=0.016 and P=0.024). Conclusion. Correlations between SNPs, salt taste sensitivity, and hypertension risk were observed. People with hypertension had a higher salt taste threshold than those with normotension. |
| format | Article |
| id | doaj-art-20921f817e7340fe9a1bb2df5c0b927d |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-20921f817e7340fe9a1bb2df5c0b927d2025-02-03T01:25:18ZengWileyInternational Journal of Hypertension2090-03842090-03922021-01-01202110.1155/2021/55598315559831Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive AdultsPradtana Tapanee0Diane K. Tidwell1M. Wes Schilling2Daniel G. Peterson3Terezie Tolar-Peterson4Department of Food Science, Nutrition, and Health Promotion, Mississippi State University, Starkville 39762, MS, USADepartment of Food Science, Nutrition, and Health Promotion, Mississippi State University, Starkville 39762, MS, USADepartment of Food Science, Nutrition, and Health Promotion, Mississippi State University, Starkville 39762, MS, USAInstitute for Genomics Biocomputing and Biotechnology, Mississippi State University, Starkville 39762, MS, USADepartment of Food Science, Nutrition, and Health Promotion, Mississippi State University, Starkville 39762, MS, USABackground. Different taste preferences correlated with genetic variations may lead to food consumption patterns that contribute to nutrient-related health outcomes such as hypertension. Objectives. The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) in the salt taste receptor genes SCNN1B and TRPV1 affect salt taste perception among normotensive and hypertensive people. Materials and Methods. We conducted a cross-sectional case control study by design consisting of a normotensive and hypertensive group. Participants were 253 adults with age range of 20–82 residing in Mississippi, USA. For each of 128 normotensives and 125 hypertensives, the salt taste recognition threshold and salt taste receptor genotype were determined. Results. The hypertensive group had a higher salt taste recognition threshold than the normotensive group (P<0.001). The polymorphism of TRPV1, rs4790522, with the AA genotype was associated with a higher salt recognition threshold (lower salt taste sensitivity) in people with hypertension and obesity. Moreover, the polymorphism of TRPV1, rs8065080, and SCNN1B, rs239345, genes were associated with a risk of hypertension (P=0.016 and P=0.024). Conclusion. Correlations between SNPs, salt taste sensitivity, and hypertension risk were observed. People with hypertension had a higher salt taste threshold than those with normotension.http://dx.doi.org/10.1155/2021/5559831 |
| spellingShingle | Pradtana Tapanee Diane K. Tidwell M. Wes Schilling Daniel G. Peterson Terezie Tolar-Peterson Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults International Journal of Hypertension |
| title | Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults |
| title_full | Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults |
| title_fullStr | Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults |
| title_full_unstemmed | Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults |
| title_short | Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults |
| title_sort | genetic variation in taste receptor genes scnn1b trpv1 and its correlation with the perception of saltiness in normotensive and hypertensive adults |
| url | http://dx.doi.org/10.1155/2021/5559831 |
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